| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253308 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 22613833 |
The loss of QBRICK significantly diminished the expression of nephronectin, an integrin α8β1 ligand necessary for renal development. In vivo, nephronectin associated with QBRICK and localized at the sublamina densa region, where QBRICK was also located. Collectively, these findings indicate that QBRICK facilitates the integrin α8β1-dependent interactions of cells with basement membranes by regulating the basement membrane assembly of nephronectin and explain why renal defects occur in Fraser syndrome. |
|
3.0
FREM1
- 
- 
transcriptional regulation