4.0
Summary
| Name |  NOMO2
|
| Full Name | BOS complex subunit NOMO2 |
| Synonyms | Nodal modulator 2, pM5 protein 2 | |
| Primary ID | Q5JPE7 |
| Links |  -  -  |
| Type | protein |
| Relations | 1 |
| Function | Component of the multi-pass translocon (MPT) complex that mediates insertion of multi-pass membrane proteins into the lipid bilayer of membranes (PubMed:32820719, PubMed:36261522). The MPT complex takes over after the SEC61 complex: following membrane insertion of the first few transmembrane segments of proteins by the SEC61 complex, the MPT complex occludes the lateral gate of the SEC61 complex to promote insertion of subsequent transmembrane regions (PubMed:36261522). |
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Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | NOMO2 | form complex 
binding
|
BOS complex, NOMO2 variant | 0.496 |
| Publications: | 1 | Organism: | Homo Sapiens | |