| + |
SOHLH1 | up-regulates quantity by expression 
transcriptional regulation
|
ZP1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266077 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 16690745 |
Cotransfection of a mouse Sohlh1 expression vector with E box-containing promoter regions of mouse Lhx8, Zp1, and Zp3 fused to luciferase resulted in significant transactivation . Mutation of the E box sequences abolished SOHLH1-dependent stimulation. Thus, Lhx8, Zp1, and Zp3 are likely direct downstream target genes of SOHLH1 through the E box elements in their promoters. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SOHLH1 | up-regulates quantity by expression
transcriptional regulation
|
KIT |
0.355 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266205 |
|
|
|
HEK-293T Cell |
| pmid |
sentence |
| 22328502 |
Our results suggest that SOHLH1 and SOHLH2 directly stimulate Kit transcription in postnatal spermatogonia, thus activating the signaling involved in spermatogonia differentiation and spermatogenetic progression. |
|
| Publications: |
1 |
| + |
SOHLH1 | up-regulates quantity by expression
transcriptional regulation
|
ZP3 |
0.388 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266078 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 16690745 |
Cotransfection of a mouse Sohlh1 expression vector with E box-containing promoter regions of mouse Lhx8, Zp1, and Zp3 fused to luciferase resulted in significant transactivation . Mutation of the E box sequences abolished SOHLH1-dependent stimulation. Thus, Lhx8, Zp1, and Zp3 are likely direct downstream target genes of SOHLH1 through the E box elements in their promoters. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SOHLH1 | up-regulates quantity by expression
transcriptional regulation
|
LHX8 |
0.502 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266076 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 16690745 |
Cotransfection of a mouse Sohlh1 expression vector with E box-containing promoter regions of mouse Lhx8, Zp1, and Zp3 fused to luciferase resulted in significant transactivation . Mutation of the E box sequences abolished SOHLH1-dependent stimulation. Thus, Lhx8, Zp1, and Zp3 are likely direct downstream target genes of SOHLH1 through the E box elements in their promoters. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
SOHLH1
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