3.0
Summary
| Name |  GNAS
|
| Full Name | Guanine nucleotide-binding protein G |
| Synonyms | Adenylate cyclase-stimulating G alpha protein, Extra large alphas protein, XLalphas | GNAS1 |
| Primary ID | Q5JWF2 |
| Links |  -  -  |
| Type | protein |
| Relations | 4 |
| Function | Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein-coupled receptors (GPCRs). Signaling involves the activation of adenylyl cyclases, resulting in increased levels of the signaling molecule cAMP. GNAS functions downstream of several GPCRs, including beta-adrenergic receptors. XLas isoforms interact with the same set of receptors as GNAS isoforms (By similarity). |
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Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | GNAS | down-regulates activity 
binding
|
RACK1 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | MC3R | up-regulates activity 
|
GNAS | 0.544 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | MC4R | up-regulates activity
|
GNAS | 0.518 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | LPAR6 | up-regulates activity
binding
|
GNAS | 0.32 |
| Publications: | 1 | Organism: | Homo Sapiens | |