3.0
Summary
| Name |  WDR45B
|
| Full Name | WD repeat domain phosphoinositide-interacting protein 3 |
| Synonyms | WIPI-3, WD repeat-containing protein 45-like, WDR45-like protein, WD repeat-containing protein 45B, WIPI49-like protein | WDR45L, WIPI3 |
| Primary ID | Q5MNZ6 |
| Links |  -  -  |
| Type | protein |
| Relations | 2 |
| Function | Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation (PubMed:28561066). Binds phosphatidylinositol 3-phosphate (PtdIns3P) forming on membranes of the endoplasmic reticulum upon activation of the upstream ULK1 and PI3 kinases and is recruited at phagophore assembly sites where it regulates the elongation of nascent phagophores downstream of WIPI2 (PubMed:28561066). In the cellular response to starvation, may also function together with the TSC1-TSC2 complex and RB1CC1 in the inhibition of the mTORC1 signaling pathway (PubMed:28503735). |
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