Relation Results

Summary

Name MAP3K21
Full Name Mitogen-activated protein kinase kinase kinase 21
Synonyms Mitogen-activated protein kinase kinase kinase MLK4, Mixed lineage kinase 4 | KIAA1804, MLK4
Primary ID Q5TCX8
Links - -
Type protein
Relations 2
Function Negative regulator of TLR4 signaling. Does not activate JNK1/MAPK8 pathway, p38/MAPK14, nor ERK2/MAPK1 pathways.

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Type: Score: Layout: SPV 
0.2MAP3K21MAP2K1

Modifications Tables

Relations

Regulator
Mechanism
target
score
+ up-regulates activity img/direct-activation.png phosphorylation MAP2K1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-260767 Ser218 VSGQLIDsMANSFVG Homo sapiens
pmid sentence
These experiments showed that MEK1 is phosphorylated by MLK4 on Ser217/221
Identifier Residue Sequence Organism Cell Line
SIGNOR-260768 Ser222 LIDSMANsFVGTRSY Homo sapiens
pmid sentence
These experiments showed that MEK1 is phosphorylated by MLK4 on Ser217/221
Publications: 2 Organism: Homo Sapiens
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