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Summary
Name
MAP3K21
View Modifications
Full Name
Mitogen-activated protein kinase kinase kinase 21
Synonyms
Mitogen-activated protein kinase kinase kinase MLK4, Mixed lineage kinase 4 | KIAA1804, MLK4
Primary ID
Q5TCX8
Links
-
-
Type
protein
Relations
2
Function
Negative regulator of TLR4 signaling. Does not activate JNK1/MAPK8 pathway, p38/MAPK14, nor ERK2/MAPK1 pathways.
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Refine search:
by mechanism
none
phosphorylation
by effect
none
up-regulates activity
by organism:
none
Homo sapiens
by tissue:
none
by cell-line
none
▶
Modifications Tables
MAP3K21 as Modifier
Residue
Sequence
Target
Effect
Modification
Ser218
VSGQLIDsMANSFVG
MAP2K1
activation
phosphorylation
Ser222
LIDSMANsFVGTRSY
MAP2K1
activation
phosphorylation
Relations
Regulator
Mechanism
target
score
ℹ
+
MAP3K21
up-regulates activity
phosphorylation
MAP2K1
0.2
Identifier
Residue
Sequence
Organism
Cell Line
SIGNOR-260767
Ser218
VSGQLIDsMANSFVG
Homo sapiens
pmid
sentence
23319808
These experiments showed that MEK1 is phosphorylated by MLK4 on Ser217/221
Identifier
Residue
Sequence
Organism
Cell Line
SIGNOR-260768
Ser222
LIDSMANsFVGTRSY
Homo sapiens
pmid
sentence
23319808
These experiments showed that MEK1 is phosphorylated by MLK4 on Ser217/221
Publications:
2
Organism:
Homo Sapiens