Summary

Name HACD4
Full Name Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 4
Synonyms 3-hydroxyacyl-CoA dehydratase 4, HACD4, Protein-tyrosine phosphatase-like A domain-containing protein 2 | PTPLAD2
Primary ID Q5VWC8
Links - -
Type protein
Relations 1
Function Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.

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Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png chemical activation FASN 0.2
Publications: 1 Organism: Homo Sapiens