Summary

Name LPCAT4
Full Name Lysophospholipid acyltransferase LPCAT4
Synonyms 1-acylglycerol-3-phosphate O-acyltransferase 7, 1-AGP acyltransferase 7, 1-AGPAT 7, 1-acylglycerophosphocholine O-acyltransferase, EC 2.3.1.23, 1-acylglycerophosphoserine O-acyltransferase, EC 2.3.1.n6, 1-alkenylglycerophosphoethanolamine O-acyltransferase, EC 2.3.1.121, 1-alkylglycerophosphocholine O-acetyltransferase, EC 2.3.1.67, Acyltransferase-like 3, Lysophosphatidylcholine acyltransferase 4, Lysophosphatidylethanolamine acyltransferase 2, EC 2.3.1.n7, Plasmalogen synthase | AGPAT7, AYTL3, LPEAT2
Primary ID Q643R3
Links - -
Type protein
Relations 4
Function Displays acyl-CoA-dependent lysophospholipid acyltransferase activity with a subset of lysophospholipids as substrates; converts lysophosphatidylethanolamine to phosphatidylethanolamine, lysophosphatidylcholine to phosphatidycholine, 1-alkenyl-lysophatidylethanolamine to 1-alkenyl-phosphatidylethanolamine, lysophosphatidylglycerol and alkyl-lysophosphatidylcholine to phosphatidylglycerol and alkyl-phosphatidylcholine, respectively. In contrast, has no lysophosphatidylinositol, glycerol-3-phosphate, diacylglycerol or lysophosphatidic acid acyltransferase activity. Prefers long chain acyl-CoAs (C16, C18) as acyl donors. {ECO:0000269|PubMed:18458083}.

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Relations

Regulator Mechanism target score
+ down-regulates quantity img/direct_inhibition.png chemical modification 1-O-acyl-sn-glycero-3-phosphocholine 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity img/direct-activation.png chemical modification 1,2-diacyl-sn-glycero-3-phosphocholine 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity img/direct-activation.png chemical modification coenzyme A(4-) 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity img/direct_inhibition.png chemical modification acyl-CoA(4-) 0.8
Publications: 1 Organism: Homo Sapiens