| + |
TRIM68 | down-regulates quantity by destabilization 
ubiquitination
|
TFG |
0.459 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278737 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24999993 |
Our results suggest that TRIM68 degrades TFG at a point of pathway convergence in which downstream events lead to the activation of both NF-kappaB and IRF3.|TRIM68 polyubiquitinates TFG leading to its degradation via its RING domain which also plays an important role in TRIM68 negative inhibition on IFN-beta production. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TRIM68 | down-regulates quantity
ubiquitination
|
TFG |
0.459 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278738 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24999993 |
Having shown that TFG positively influences IFN-\u03b2 production and TRIM68 promotes ubiquitination and degradation of TFG, we next set out to determine whether this ubiquitination was involved in the inhibition of IFN-\u03b2 signalling.|Our results suggest that TRIM68 degrades TFG at a point of pathway convergence in which downstream events lead to the activation of both NF-kappaB and IRF3. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Ub:E2 | up-regulates activity 
ubiquitination
|
TRIM68 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271169 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 34199813 |
The ubiquitination process is mediated sequentially by three classes of enzymes consisting of a Ub-activating enzyme E1, a Ub-conjugating enzyme E2, and a Ub ligase E3. Ub is first activated by E1 in an adenosine 5′-triphosphate (ATP)-dependent manner t |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
TRIM68
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