| + |
TRIM68 | down-regulates quantity by destabilization 
ubiquitination
|
TFG |
0.459 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278737 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24999993 |
Our results suggest that TRIM68 degrades TFG at a point of pathway convergence in which downstream events lead to the activation of both NF-kappaB and IRF3.|TRIM68 polyubiquitinates TFG leading to its degradation via its RING domain which also plays an important role in TRIM68 negative inhibition on IFN-beta production. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TRIM68 | down-regulates quantity
ubiquitination
|
TFG |
0.459 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278738 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24999993 |
Having shown that TFG positively influences IFN-\u03b2 production and TRIM68 promotes ubiquitination and degradation of TFG, we next set out to determine whether this ubiquitination was involved in the inhibition of IFN-\u03b2 signalling.|Our results suggest that TRIM68 degrades TFG at a point of pathway convergence in which downstream events lead to the activation of both NF-kappaB and IRF3. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TFG | up-regulates 
binding
|
SEC16A |
0.635 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-173242 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21478858 |
We identify tfg-1, a new conserved regulator of protein secretion that interacts directly with sec-16 and controls the export of cargoes from the endoplasmic reticulum in caenorhabditis elegans. Hydrodynamic studies indicate that tfg-1 forms hexamers that facilitate the co-assembly of sec-16 with copii subunits. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TFG | up-regulates
binding
|
SEC16B |
0.487 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-173279 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21478858 |
We identify tfg-1, a new conserved regulator of protein secretion that interacts directly with sec-16 and controls the export of cargoes from the endoplasmic reticulum in caenorhabditis elegans. Hydrodynamic studies indicate that tfg-1 forms hexamers that facilitate the co-assembly of sec-16 with copii subunits. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
TFG
- 
- 