Summary

Name KDM4D
Full Name Lysine-specific demethylase 4D
Synonyms EC 1.14.11.66, JmjC domain-containing histone demethylation protein 3D, Jumonji domain-containing protein 2D, [histone H3]-trimethyl-L-lysine(9 | JHDM3D, JMJD2D
Primary ID Q6B0I6
Links - -
Type protein
Relations 1
Function Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Demethylates both di- and trimethylated H3 'Lys-9' residue, while it has no activity on monomethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. {ECO:0000269|PubMed:16603238}.

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Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png chemical activation KDM4D 0.8
Publications: 1