4.0
Summary
| Name |  SIGIRRView Modifications |
| Full Name | Single Ig IL-1-related receptor |
| Synonyms | Single Ig IL-1R-related molecule, Single immunoglobulin domain-containing IL1R-related protein, Toll/interleukin-1 receptor 8, TIR8 | |
| Primary ID | Q6IA17 |
| Links |  -  -  |
| Type | protein |
| Relations | 2 |
| Function | Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP. {ECO:0000269|PubMed:12925853, ECO:0000269|PubMed:14715412, ECO:0000269|PubMed:15866876, ECO:0000269|PubMed:25963006}. |
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