| + |
IL37 | down-regulates activity 
binding
|
Interleukin-37 receptor-ligand complex |
0.6 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-281100 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 27060871 |
IL-37 binds to the IL-18 receptor but then recruits the orphan IL-1R8 (formerly TIR8 or SIGIRR) in order to function as an inhibitor. Here, we review the discovery of IL-37, its production, release, and mechanisms by which IL-37 reduces inflammation and suppresses immune responses. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IL18R1 | form complex 
binding
|
Interleukin-37 receptor-ligand complex |
0.445 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-281098 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 27060871 |
IL-37 binds to the IL-18 receptor but then recruits the orphan IL-1R8 (formerly TIR8 or SIGIRR) in order to function as an inhibitor. Here, we review the discovery of IL-37, its production, release, and mechanisms by which IL-37 reduces inflammation and suppresses immune responses. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SIGIRR | form complex
binding
|
Interleukin-37 receptor-ligand complex |
0.445 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-281099 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 27060871 |
IL-37 binds to the IL-18 receptor but then recruits the orphan IL-1R8 (formerly TIR8 or SIGIRR) in order to function as an inhibitor. Here, we review the discovery of IL-37, its production, release, and mechanisms by which IL-37 reduces inflammation and suppresses immune responses. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Interleukin-37 receptor-ligand complex | down-regulates
|
Inflammation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-281101 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 27060871 |
IL-37 binds to the IL-18 receptor but then recruits the orphan IL-1R8 (formerly TIR8 or SIGIRR) in order to function as an inhibitor. Here, we review the discovery of IL-37, its production, release, and mechanisms by which IL-37 reduces inflammation and suppresses immune responses. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
4.0
Interleukin-37 receptor-ligand complex