Summary

Name PRR5L
Full Name Proline-rich protein 5-like
Synonyms Protein observed with Rictor-2, Protor-2 | PROTOR2
Primary ID Q6MZQ0
Links - -
Type protein
Relations 1
Function Associates with the mTORC2 complex that regulates cellular processes including survival and organization of the cytoskeleton (PubMed:17461779). Regulates the activity of the mTORC2 complex in a substrate-specific manner preventing for instance the specific phosphorylation of PKCs and thereby controlling cell migration (PubMed:22609986). Plays a role in the stimulation of ZFP36-mediated mRNA decay of several ZFP36-associated mRNAs, such as TNF-alpha and GM-CSF, in response to stress (PubMed:21964062). Required for ZFP36 localization to cytoplasmic stress granule (SG) and P-body (PB) in response to stress (PubMed:21964062). {ECO:0000269|PubMed:17461779, ECO:0000269|PubMed:21964062, ECO:0000269|PubMed:22609986}.

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Relations

Regulator Mechanism target score ℹ
+ RFFLdown-regulates quantity by destabilization img/direct_inhibition.png polyubiquitination PRR5L 0.264
Publications: 1 Organism: Homo Sapiens