| + |
ZNF774 | up-regulates activity 
binding
|
MBD2/NuRD complex |
0.25 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265558 |
|
|
Homo sapiens |
Hepatoma Cell Line |
| pmid |
sentence |
| 31659254 |
Here we report that ZNF774, a novel zinc-finger protein, inhibits the proliferation and invasion of HCC cells. Molecular characterization of this protein indicated that ZNF774 acts as a transcription repressor, and interrogation of ZNF774 interactome by affinity purification-coupled mass spectrometry revealed that ZNF774 is physically associated with the Mi-2/nucleosome remodeling and deacetylase (NuRD) complex in cells. We demonstrated that ZNF774 recruits the NuRD complex to the NOTCH2 promoter and represses NOTCH2 transcription. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ZNF774 | up-regulates activity
binding
|
MBD3/NuRD complex |
0.25 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265559 |
|
|
Homo sapiens |
Hepatoma Cell Line |
| pmid |
sentence |
| 31659254 |
Here we report that ZNF774, a novel zinc-finger protein, inhibits the proliferation and invasion of HCC cells. Molecular characterization of this protein indicated that ZNF774 acts as a transcription repressor, and interrogation of ZNF774 interactome by affinity purification-coupled mass spectrometry revealed that ZNF774 is physically associated with the Mi-2/nucleosome remodeling and deacetylase (NuRD) complex in cells. We demonstrated that ZNF774 recruits the NuRD complex to the NOTCH2 promoter and represses NOTCH2 transcription. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
ZNF774
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