Summary

Name CDC73
Full Name Parafibromin
Synonyms Cell division cycle protein 73 homolog, Hyperparathyroidism 2 protein | C1orf28, HRPT2
Primary ID Q6P1J9
Links - -
Type protein
Relations 4
Function Tumor suppressor probably involved in transcriptional and post-transcriptional control pathways. May be involved in cell cycle progression through the regulation of cyclin D1/PRAD1 expression. Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Connects PAF1C with the cleavage and polyadenylation specificity factor (CPSF) complex and the cleavage stimulation factor (CSTF) complex, and with Wnt signaling. Involved in polyadenylation of mRNA precursors.

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Relations

Regulator Mechanism target score ℹ
+ CDC73up-regulates img/direct-activation.png binding CTNNB1 0.694
Publications: 1 Organism: Homo Sapiens
+ CDC73form complex img/form-complex.png binding PAF1C 0.933
Publications: 1 Organism: Homo Sapiens
+ PTPN11up-regulates activity img/direct-activation.png dephosphorylation CDC73 0.494
Publications: 1 Organism: Homo Sapiens
+ PTK6down-regulates activity img/direct_inhibition.png phosphorylation CDC73 0.368
Publications: 1 Organism: Homo Sapiens