Summary

Name CTNNB1
Full Name Catenin beta-1
Synonyms Beta-catenin | CTNNB
Primary ID P35222
Links - -
Type protein
Relations 148
Pathways WNT Signaling, WNT Signaling and Myogenesis, Colorectal Carcinoma, Rhabdomyosarcoma, Thyroid cancer, PPARgamma in cancer, AML1-ETO in AML
Function Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion, as component of an E-cadherin:catenin adhesion complex. Acts as a negative regulator of centrosome cohesion. Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization. Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2. Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22647378, PubMed:22699938, PubMed:22155184). Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle (By similarity).

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png trimethylation HIST1H3A 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CTNNB1 0.31
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation CTNNB1 0.14
Publications: 3 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation CTNNB1 0.28
Publications: 4 Organism: Homo Sapiens, Chlorocebus Aethiops
+ down-regulates activity img/direct_inhibition.png phosphorylation CTNNB1 0.48
Publications: 11 Organism: Homo Sapiens
Tissue: Brain, Colonic Cancer Cell
+ down-regulates activity img/direct_inhibition.png phosphorylation CTNNB1 0.45
Publications: 10 Organism: Homo Sapiens
Tissue: Colonic Cancer Cell, Brain
Pathways:Colorectal Carcinoma, WNT Signaling, WNT Signaling and Myogenesis
+ down-regulates img/direct_inhibition.png phosphorylation CTNNB1 0.2
Publications: 3 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation CTNNB1 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation CTNNB1 0.14
Publications: 1 Organism: In Vitro
+ down-regulates img/direct_inhibition.png phosphorylation CTNNB1 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CTNNB1 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CTNNB1 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CTNNB1 0.22
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation CTNNB1 0.34
Publications: 3 Organism: Homo Sapiens
Pathways:WNT Signaling, WNT Signaling and Myogenesis
+ up-regulates img/direct-activation.png phosphorylation CTNNB1 0.31
Publications: 2 Organism: Homo Sapiens
Pathways:Rhabdomyosarcoma, Thyroid cancer
+ up-regulates img/direct-activation.png phosphorylation CTNNB1 0.22
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CTNNB1 0.14
Publications: 3 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CTNNB1 0.28
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CTNNB1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CTNNB1 0.14
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation CTNNB1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CTNNB1 0.14
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation CTNNB1 0.14
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png phosphorylation CTNNB1 0.22
Publications: 1 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation CTNNB1 0.34
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
Pathways:Rhabdomyosarcoma
+ up-regulates img/direct-activation.png phosphorylation CTNNB1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation CTNNB1 0.34
Publications: 1 Organism: Homo Sapiens
Pathways:Rhabdomyosarcoma
+ down-regulates img/direct_inhibition.png phosphorylation CTNNB1 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation CTNNB1 0.28
Publications: 1 Organism: Homo Sapiens
Pathways:Rhabdomyosarcoma
+ down-regulates img/direct_inhibition.png ubiquitination CTNNB1 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding CTNNB1 0.34
Publications: 1 Organism: Homo Sapiens
Tissue: Brain, Kidney, Lung
+ down-regulates img/direct_inhibition.png binding CTNNB1 0.45
Publications: 2 Organism: Homo Sapiens, Chlorocebus Aethiops
Pathways:Colorectal Carcinoma, WNT Signaling, WNT Signaling and Myogenesis
+ up-regulates activity img/direct-activation.png binding LEF1 0.91
Publications: 3 Organism: Homo Sapiens
Pathways:Colorectal Carcinoma, WNT Signaling, WNT Signaling and Myogenesis
+ down-regulates activity img/direct_inhibition.png binding CTNNB1 0.36
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png ubiquitination CTNNB1 0.35
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding CTNNB1 0.42
Publications: 1 Organism: In Vitro
+ img/unknown.png binding CTNNB1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CCND1 0.2
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding MYOD1 0.22
Publications: 2 Organism: Homo Sapiens,
Tissue: Muscle
Pathways:Rhabdomyosarcoma, WNT Signaling and Myogenesis
+ down-regulates activity img/direct_inhibition.png binding SOX2 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding CTNNB1 0.36
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CLDN2 0.14
Publications: 1 Organism: Mus Musculus
+ up-regulates img/indirect-activation.png CTNNB1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png dephosphorylation CTNNB1 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation CTNNB1 0.22
Publications: 1 Organism: Homo Sapiens
Pathways:PPARgamma in cancer, Thyroid cancer
+ down-regulates img/direct_inhibition.png binding CTNNB1 0.38
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding NOTCH1 0.14
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity img/direct-activation.png transcriptional regulation WISP1 0.14
Publications: 1 Organism: Rattus Norvegicus
+ up-regulates img/direct-activation.png binding EP300 0.48
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/indirect-activation.png CTNNB1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation FOXA2 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding CTNNB1 0.48
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png PPARG 0.28
Publications: 1 Organism: Homo Sapiens
Pathways:PPARgamma in cancer, Thyroid cancer
+ up-regulates img/indirect-activation.png RUNX2 0.2
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding CTNNB1 0.42
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding CTNNB1 0.42
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png CTNNB1 0.2
Publications: 1
Tissue: Skeletal Muscle
Pathways:WNT Signaling, WNT Signaling and Myogenesis
+ down-regulates img/direct_inhibition.png binding CTNNB1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding TRRAP 0.28
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png CTNNB1 0.34
Publications: 1 Organism: Homo Sapiens
Tissue: Breast
+ down-regulates img/direct_inhibition.png binding CTNNB1 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png CTNNB1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity img/direct-activation.png deacetylation CTNNB1 0.14
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity by expression img/indirect-activation.png transcriptional activation AFF3 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png Metastasis 0.14
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CTNNB1 0.31
Publications: 1 Organism: Homo Sapiens
Pathways:Rhabdomyosarcoma, Thyroid cancer
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CTNNB1 0.28
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation MYC 0.37
Publications: 2 Organism: Homo Sapiens
Pathways:Colorectal Carcinoma, Rhabdomyosarcoma, Thyroid cancer, WNT Signaling
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation CTNNB1 0.22
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding CTNNB1 0.44
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding CTNNB1 0.22
Publications: 1 Organism: Homo Sapiens
Tissue: Heart
+ up-regulates img/indirect-activation.png Proliferation 0.59
Publications: 2 Organism: Homo Sapiens
Pathways:AML1-ETO in AML, Colorectal Carcinoma, PPARgamma in cancer, Rhabdomyosarcoma, Thyroid cancer, WNT Signaling
+ down-regulates quantity by destabilization img/direct_inhibition.png relocalization CTNNB1 0.34
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png CTNNB1 0.2
Publications: 1
Pathways:WNT Signaling, WNT Signaling and Myogenesis
+ up-regulates activity img/direct-activation.png binding TCF4 0.45
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity img/indirect_inhibition.png relocalization CTNNB1 0.14
Publications: 1 Organism: Mus Musculus
+ down-regulates img/direct_inhibition.png binding CTNNB1 0.36
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png CTNNB1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CTNNB1 0.28
Publications: 1 Organism: Xenopus Laevis
Pathways:WNT Signaling, WNT Signaling and Myogenesis
+ down-regulates quantity img/direct_inhibition.png binding CTNNB1 0.37
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding CTNNB1 0.5
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding TCF7 0.3
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png binding CTNNB1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/indirect-activation.png CTNNB1 0.14
Publications: 1
+ up-regulates img/direct-activation.png binding CTNNB1 0.44
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png binding CTNNB1 0.14
Publications: 1 Organism: Homo Sapiens
Pathways:WNT Signaling, WNT Signaling and Myogenesis
+ down-regulates activity img/direct_inhibition.png binding CTNNB1 0.14
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png binding TCF7L2 0.63
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png CTNNB1 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding PPARG 0.28
Publications: 1 Organism: Mus Musculus
Pathways:PPARgamma in cancer, Thyroid cancer
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation CTNNB1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding CTNNB1 0.14
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle
+ up-regulates img/indirect-activation.png CTNNB1 0.14
Publications: 1 Organism: Homo Sapiens
Pathways:AML1-ETO in AML
+ up-regulates activity img/direct-activation.png binding POU5F1 0.14
Publications: 1 Organism: Mus Musculus
+ down-regulates img/indirect_inhibition.png CTNNB1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png CTNNB1 0.22
Publications: 1 Organism: Rattus Norvegicus
Pathways:Colorectal Carcinoma, WNT Signaling, WNT Signaling and Myogenesis
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination CTNNB1 0.22
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png CEBPA 0.14
Publications: 1 Organism: Homo Sapiens
Pathways:AML1-ETO in AML
+ down-regulates img/indirect_inhibition.png transcriptional regulation CTNNB1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding KLF4 0.14
Publications: 1 Organism: Mus Musculus
Tissue: HEK-293T Cell
+ up-regulates activity img/direct-activation.png binding SOX2 0.14
Publications: 1 Organism: Mus Musculus
Tissue: HEK-293T Cell
+ up-regulates activity img/direct-activation.png binding CTNNB1 0.34
Publications: 2 Organism: Homo Sapiens
Pathways:AML1-ETO in AML
+ up-regulates img/indirect-activation.png CTNNB1 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding CTNNB1 0.34
Publications: 1 Organism: Homo Sapiens