| + |
SCF(TBL1) | down-regulates quantity by destabilization 
polyubiquitination
|
CTNNB1 |
0.721 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271946 |
Lys666 |
LFRMSEDkPQDYKKR |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 20181957 |
Upon UV-induced DNA damage, beta-catenin is recruited for polyubiquitination and subsequent proteasomal degradation by a unique, p53-induced SCF-like complex (SCF(TBL1)), comprised of Siah-1, Siah-1-interacting protein (SIP), Skp1, transducin beta-like 1 (TBL1), and adenomatous polyposis coli (APC). |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271947 |
Lys671 |
EDKPQDYkKRLSVEL |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 20181957 |
Upon UV-induced DNA damage, beta-catenin is recruited for polyubiquitination and subsequent proteasomal degradation by a unique, p53-induced SCF-like complex (SCF(TBL1)), comprised of Siah-1, Siah-1-interacting protein (SIP), Skp1, transducin beta-like 1 (TBL1), and adenomatous polyposis coli (APC). |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
CDK5 | up-regulates activity 
phosphorylation
|
CTNNB1 |
0.381 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279515 |
Ser191 |
SRHAIMRsPQMVSAI |
Homo sapiens |
|
| pmid |
sentence |
| 26509276 |
By combining multiple network relations with PTM proteoform specific functional information, we proposed a mechanism to explain the observation that the cyclin dependent kinase CDK5 positively regulates beta-catenin co-activator activity.|CDK5 phosphorylates beta-catenin on Ser-191 and Ser-246 (PR:000037229) |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279516 |
Ser246 |
ALVKMLGsPVDSVLF |
Homo sapiens |
|
| pmid |
sentence |
| 26509276 |
By combining multiple network relations with PTM proteoform specific functional information, we proposed a mechanism to explain the observation that the cyclin dependent kinase CDK5 positively regulates beta-catenin co-activator activity.|CDK5 phosphorylates beta-catenin on Ser 191 and Ser 246 (PR :000037229) |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
MAPK9 | up-regulates
phosphorylation
|
CTNNB1 |
0.663 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-178258 |
Ser191 |
SRHAIMRsPQMVSAI |
Homo sapiens |
|
| pmid |
sentence |
| 18423204 |
Beta-catenin, upon entering the nucleus, in turn activates transcription of downstream target genes. Jnk2 phosphorylates Beta-catenin on critical residues (ser191 and ser605). Jnk activity is required for Beta-catenin nuclear localization in response to wnt. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-178262 |
Ser605 |
LFVQLLYsPIENIQR |
Homo sapiens |
|
| pmid |
sentence |
| 18423204 |
Beta-catenin, upon entering the nucleus, in turn activates transcription of downstream target genes. Jnk2 phosphorylates Beta-catenin on critical residues (ser191 and ser605). Jnk activity is required for Beta-catenin nuclear localization in response to wnt. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
CSNK2A1 | up-regulates quantity by stabilization
phosphorylation
|
CTNNB1 |
0.547 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275998 |
Ser29 |
VSHWQQQsYLDSGIH |
in vitro |
|
| pmid |
sentence |
| 12432063 |
We show that CKII phosphorylates the N-terminal region of beta-catenin and we identified Ser29, Thr102, and Thr112 as substrates for the enzyme. We provide evidence that CKII regulates the cytoplasmic stability of beta-catenin and acts synergistically with GSK-3beta in the multi-protein complex that controls the degradation of beta-catenin. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275996 |
Thr102 |
RAAMFPEtLDEGMQI |
in vitro |
|
| pmid |
sentence |
| 12432063 |
We show that CKII phosphorylates the N-terminal region of beta-catenin and we identified Ser29, Thr102, and Thr112 as substrates for the enzyme. We provide evidence that CKII regulates the cytoplasmic stability of beta-catenin and acts synergistically with GSK-3beta in the multi-protein complex that controls the degradation of beta-catenin. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275997 |
Thr112 |
EGMQIPStQFDAAHP |
in vitro |
|
| pmid |
sentence |
| 12432063 |
We show that CKII phosphorylates the N-terminal region of beta-catenin and we identified Ser29, Thr102, and Thr112 as substrates for the enzyme. We provide evidence that CKII regulates the cytoplasmic stability of beta-catenin and acts synergistically with GSK-3beta in the multi-protein complex that controls the degradation of beta-catenin. |
|
| Publications: |
3 |
Organism: |
In Vitro |
| Pathways: | Neurotransmitters release |
| + |
CSNK2B | up-regulates activity
phosphorylation
|
CTNNB1 |
0.593 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251065 |
Ser29 |
VSHWQQQsYLDSGIH |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 12432063 |
We show that CKII phosphorylates the N-terminal region of beta-catenin and we identified Ser29, Thr102, and Thr112 as substrates for the enzyme. We provide evidence that CKII regulates the cytoplasmic stability of beta-catenin and acts synergistically with GSK-3beta in the multi-protein complex that controls the degradation of beta-catenin |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251066 |
Thr102 |
RAAMFPEtLDEGMQI |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 12432063 |
We show that CKII phosphorylates the N-terminal region of beta-catenin and we identified Ser29, Thr102, and Thr112 as substrates for the enzyme. We provide evidence that CKII regulates the cytoplasmic stability of beta-catenin and acts synergistically with GSK-3beta in the multi-protein complex that controls the degradation of beta-catenin |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251067 |
Thr112 |
EGMQIPStQFDAAHP |
Homo sapiens |
|
| pmid |
sentence |
| 12432063 |
We show that CKII phosphorylates the N-terminal region of beta-catenin and we identified Ser29, Thr102, and Thr112 as substrates for the enzyme. We provide evidence that CKII regulates the cytoplasmic stability of beta-catenin and acts synergistically with GSK-3beta in the multi-protein complex that controls the degradation of beta-catenin |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| + |
CSNK2A2 | up-regulates quantity by stabilization
phosphorylation
|
CTNNB1 |
0.466 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275995 |
Ser29 |
VSHWQQQsYLDSGIH |
in vitro |
|
| pmid |
sentence |
| 12432063 |
We show that CKII phosphorylates the N-terminal region of beta-catenin and we identified Ser29, Thr102, and Thr112 as substrates for the enzyme. We provide evidence that CKII regulates the cytoplasmic stability of beta-catenin and acts synergistically with GSK-3beta in the multi-protein complex that controls the degradation of beta-catenin. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275993 |
Thr102 |
RAAMFPEtLDEGMQI |
in vitro |
|
| pmid |
sentence |
| 12432063 |
We show that CKII phosphorylates the N-terminal region of beta-catenin and we identified Ser29, Thr102, and Thr112 as substrates for the enzyme. We provide evidence that CKII regulates the cytoplasmic stability of beta-catenin and acts synergistically with GSK-3beta in the multi-protein complex that controls the degradation of beta-catenin. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275994 |
Thr112 |
EGMQIPStQFDAAHP |
in vitro |
|
| pmid |
sentence |
| 12432063 |
We show that CKII phosphorylates the N-terminal region of beta-catenin and we identified Ser29, Thr102, and Thr112 as substrates for the enzyme. We provide evidence that CKII regulates the cytoplasmic stability of beta-catenin and acts synergistically with GSK-3beta in the multi-protein complex that controls the degradation of beta-catenin. |
|
| Publications: |
3 |
Organism: |
In Vitro |
| + |
CSNK2A1 | up-regulates activity
phosphorylation
|
CTNNB1 |
0.547 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250846 |
Ser29 |
VSHWQQQsYLDSGIH |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 12432063 |
We show that CKII phosphorylates the N-terminal region of beta-catenin and we identified Ser29, Thr102, and Thr112 as substrates for the enzyme. We provide evidence that CKII regulates the cytoplasmic stability of beta-catenin and acts synergistically with GSK-3beta in the multi-protein complex that controls the degradation of beta-catenin |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250847 |
Thr102 |
RAAMFPEtLDEGMQI |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 12432063 |
We show that CKII phosphorylates the N-terminal region of beta-catenin and we identified Ser29, Thr102, and Thr112 as substrates for the enzyme. We provide evidence that CKII regulates the cytoplasmic stability of beta-catenin and acts synergistically with GSK-3beta in the multi-protein complex that controls the degradation of beta-catenin |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250848 |
Thr112 |
EGMQIPStQFDAAHP |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 12432063 |
We show that CKII phosphorylates the N-terminal region of beta-catenin and we identified Ser29, Thr102, and Thr112 as substrates for the enzyme. We provide evidence that CKII regulates the cytoplasmic stability of beta-catenin and acts synergistically with GSK-3beta in the multi-protein complex that controls the degradation of beta-catenin |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250849 |
Thr393 |
RNLSDAAtKQEGMEG |
Chlorocebus aethiops |
COS-7 Cell |
| pmid |
sentence |
| 12700239 |
The major CK2 phosphorylation site in this domain is Thr393, a solvent-accessible residue in a key hinge region of the molecule. Mutation of this single amino acid reduces beta-catenin phosphorylation, cotranscriptional activity, and stability. |
|
| Publications: |
4 |
Organism: |
Homo Sapiens, Chlorocebus Aethiops |
| Pathways: | Neurotransmitters release |
| + |
GSK3B/Axin/APC | down-regulates activity
phosphorylation
|
CTNNB1 |
0.894 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-227870 |
Ser33 |
QQQSYLDsGIHSGAT |
Homo sapiens |
Neuron |
| pmid |
sentence |
| 19303846 |
GSK3β regulates β-catenin stability by phosphorylating serine and threonine residues (Ser33/37 and Thr41) important for targeting β-catenin for ubiquitin-dependent proteasomal degradation |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-227897 |
Ser33 |
QQQSYLDsGIHSGAT |
Homo sapiens |
|
| pmid |
sentence |
| 11955436 |
Wnt regulation of beta-catenin degradation is essential for development and carcinogenesis. beta-catenin degradation is initiated upon amino-terminal serine/threonine phosphorylation, which is believed to be performed by glycogen synthase kinase-3 (GSK-3) in complex with tumor suppressor proteins Axin and adnomatous polyposis coli (APC). |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-227885 |
Ser33 |
QQQSYLDsGIHSGAT |
Homo sapiens |
|
| pmid |
sentence |
| 16293724 |
This leads to the inactivation and release of glycogen synthase kinase 3beta from its complex with axin, thereby relieving the inhibitory phosphorylation of beta-catenin and activating its signaling pathway. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-227874 |
Ser37 |
YLDSGIHsGATTTAP |
Homo sapiens |
Neuron |
| pmid |
sentence |
| 19303846 |
GSK3β regulates β-catenin stability by phosphorylating serine and threonine residues (Ser33/37 and Thr41) important for targeting β-catenin for ubiquitin-dependent proteasomal degradation |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-227901 |
Ser37 |
YLDSGIHsGATTTAP |
Homo sapiens |
|
| pmid |
sentence |
| 11955436 |
Wnt regulation of beta-catenin degradation is essential for development and carcinogenesis. beta-catenin degradation is initiated upon amino-terminal serine/threonine phosphorylation, which is believed to be performed by glycogen synthase kinase-3 (GSK-3) in complex with tumor suppressor proteins Axin and adnomatous polyposis coli (APC). |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-227889 |
Ser37 |
YLDSGIHsGATTTAP |
Homo sapiens |
|
| pmid |
sentence |
| 16293724 |
This leads to the inactivation and release of glycogen synthase kinase 3beta from its complex with axin, thereby relieving the inhibitory phosphorylation of beta-catenin and activating its signaling pathway. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-227878 |
Thr41 |
GIHSGATtTAPSLSG |
Homo sapiens |
Neuron |
| pmid |
sentence |
| 19303846 |
GSK3β regulates β-catenin stability by phosphorylating serine and threonine residues (Ser33/37 and Thr41) important for targeting β-catenin for ubiquitin-dependent proteasomal degradation |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-227905 |
Thr41 |
GIHSGATtTAPSLSG |
Homo sapiens |
|
| pmid |
sentence |
| 11955436 |
Wnt regulation of beta-catenin degradation is essential for development and carcinogenesis. beta-catenin degradation is initiated upon amino-terminal serine/threonine phosphorylation, which is believed to be performed by glycogen synthase kinase-3 (GSK-3) in complex with tumor suppressor proteins Axin and adnomatous polyposis coli (APC). |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260015 |
Thr41 |
GIHSGATtTAPSLSG |
in vitro |
|
| pmid |
sentence |
| 11955436 |
β-catenin degradation is initiated upon amino-terminal serine/threonine phosphorylation, which is believed to be performed by glycogen synthase kinase-3 (GSK-3) in complex with tumor suppressor proteins Axin and adnomatous polyposis coli (APC) |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-227866 |
Thr41 |
GIHSGATtTAPSLSG |
Homo sapiens |
|
| pmid |
sentence |
| 23151663 |
Beta-catenin phosphorylation in vivo is sequentially carried out by two distinct kinases, ckialfa and gsk-3. Ckialfa phosphorylation of s45 proceeds and is required for subsequent gsk-3 phosphorylation of t41, s37, and s33 one key substrate of gsk3 is the transcriptional co-activator beta catenin, whichis inactivated by gsk3 mediated phosphorylation and targeted for proteasomal degradation in unstimulated cells. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-227893 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16293724 |
Because phosphorylation of β-catenin by GSK-3β leads to its rapid ubiquitination and subsequent degradation in the proteosome, inactivation of GSK-3β is often a prerequisite for stimulating the accumulation, nuclear translocation, and functional activity of β-catenin |
|
| Publications: |
11 |
Organism: |
Homo Sapiens, In Vitro |
| Tissue: |
Brain, Colonic Cancer Cell |
| Pathways: | Colorectal Carcinoma, Hepatocellular Tumor, Wnt in cancer, WNT Signaling, WNT Signaling and Myogenesis |
| + |
PRKCA | down-regulates
phosphorylation
|
CTNNB1 |
0.417 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278492 |
Ser33 |
QQQSYLDsGIHSGAT |
Homo sapiens |
|
| pmid |
sentence |
| 25058461 |
As shown in Fig. 1 B, PKCalpha readily phosphorylated Ser33 and Ser37 / Thr41 on full-length beta-catenin (beta-catenin 1 - 781) and CTD deletion mutant (beta-catenin 1-682).|To examine the effect of the armadillo repeats 1-5 on PKCalpha mediated beta-catenin degradation, DNA constructs expressing beta-catenin 1 - 781 and beta-catenin deletion mutants (beta-catenin 1-422 and beta-catenin 1-138) were transfected into HEK293 cells, followed by treatment with increasing concentrations of A23187 and CGK062, which are known activators of PKCalpha. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278493 |
Ser37 |
YLDSGIHsGATTTAP |
Homo sapiens |
|
| pmid |
sentence |
| 25058461 |
As shown in Fig. 1 B, PKCalpha readily phosphorylated Ser33 and Ser37 / Thr41 on full-length beta-catenin (beta-catenin 1 - 781) and CTD deletion mutant (beta-catenin 1-682).|To examine the effect of the armadillo repeats 1-5 on PKCalpha mediated beta-catenin degradation, DNA constructs expressing beta-catenin 1 - 781 and beta-catenin deletion mutants (beta-catenin 1-422 and beta-catenin 1-138) were transfected into HEK293 cells, followed by treatment with increasing concentrations of A23187 and CGK062, which are known activators of PKCalpha. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278494 |
Thr41 |
GIHSGATtTAPSLSG |
Homo sapiens |
|
| pmid |
sentence |
| 25058461 |
As shown in Fig. 1 B, PKCalpha readily phosphorylated Ser33 and Ser37 / Thr41 on full-length beta-catenin (beta-catenin 1 - 781) and CTD deletion mutant (beta-catenin 1-682).|To examine the effect of the armadillo repeats 1-5 on PKCalpha mediated beta-catenin degradation, DNA constructs expressing beta-catenin 1 - 781 and beta-catenin deletion mutants (beta-catenin 1-422 and beta-catenin 1-138) were transfected into HEK293 cells, followed by treatment with increasing concentrations of A23187 and CGK062, which are known activators of PKCalpha. |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| + |
GSK3B | down-regulates activity
phosphorylation
|
CTNNB1 |
0.861 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-141799 |
Ser33 |
QQQSYLDsGIHSGAT |
Homo sapiens |
|
| pmid |
sentence |
| 16293724 |
This leads to the inactivation and release of glycogen synthase kinase 3beta from its complex with axin, thereby relieving the inhibitory phosphorylation of beta-catenin and activating its signaling pathway. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-116520 |
Ser33 |
QQQSYLDsGIHSGAT |
Homo sapiens |
|
| pmid |
sentence |
| 11955436 |
Wnt regulation of beta-catenin degradation is essential for development and carcinogenesis. beta-catenin degradation is initiated upon amino-terminal serine/threonine phosphorylation, which is believed to be performed by glycogen synthase kinase-3 (GSK-3) in complex with tumor suppressor proteins Axin and adnomatous polyposis coli (APC). |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-184781 |
Ser33 |
QQQSYLDsGIHSGAT |
Homo sapiens |
Neuron |
| pmid |
sentence |
| 19303846 |
DISC1 inhibits GSK3beta activity through direct physical interaction, which reduces beta-catenin phosphorylation and stabilizes beta-catenin. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-199504 |
Ser33 |
QQQSYLDsGIHSGAT |
Homo sapiens |
|
| pmid |
sentence |
| 23151663 |
Beta-catenin phosphorylation in vivo is sequentially carried out by two distinct kinases, ckialfa and gsk-3. Ckialfa phosphorylation of s45 proceeds and is required for subsequent gsk-3 phosphorylation of t41, s37, and s33 one key substrate of gsk3 is the transcriptional co-activator beta catenin, whichis inactivated by gsk3 mediated phosphorylation and targeted for proteasomal degradation in unstimulated cells. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-184785 |
Ser37 |
YLDSGIHsGATTTAP |
Homo sapiens |
Neuron |
| pmid |
sentence |
| 19303846 |
DISC1 inhibits GSK3beta activity through direct physical interaction, which reduces beta-catenin phosphorylation and stabilizes beta-catenin. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-116524 |
Ser37 |
YLDSGIHsGATTTAP |
Homo sapiens |
|
| pmid |
sentence |
| 11955436 |
Wnt regulation of beta-catenin degradation is essential for development and carcinogenesis. beta-catenin degradation is initiated upon amino-terminal serine/threonine phosphorylation, which is believed to be performed by glycogen synthase kinase-3 (GSK-3) in complex with tumor suppressor proteins Axin and adnomatous polyposis coli (APC). |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-141803 |
Ser37 |
YLDSGIHsGATTTAP |
Homo sapiens |
|
| pmid |
sentence |
| 16293724 |
This leads to the inactivation and release of glycogen synthase kinase 3beta from its complex with axin, thereby relieving the inhibitory phosphorylation of beta-catenin and activating its signaling pathway. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-141807 |
Thr41 |
GIHSGATtTAPSLSG |
Homo sapiens |
|
| pmid |
sentence |
| 16293724 |
This leads to the inactivation and release of glycogen synthase kinase 3beta from its complex with axin, thereby relieving the inhibitory phosphorylation of beta-catenin and activating its signaling pathway. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-184789 |
Thr41 |
GIHSGATtTAPSLSG |
Homo sapiens |
Neuron |
| pmid |
sentence |
| 19303846 |
DISC1 inhibits GSK3beta activity through direct physical interaction, which reduces beta-catenin phosphorylation and stabilizes beta-catenin. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-199512 |
Thr41 |
GIHSGATtTAPSLSG |
Homo sapiens |
|
| pmid |
sentence |
| 23151663 |
Beta-catenin phosphorylation in vivo is sequentially carried out by two distinct kinases, ckialfa and gsk-3. Ckialfa phosphorylation of s45 proceeds and is required for subsequent gsk-3 phosphorylation of t41, s37, and s33 one key substrate of gsk3 is the transcriptional co-activator beta catenin, whichis inactivated by gsk3 mediated phosphorylation and targeted for proteasomal degradation in unstimulated cells. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-116528 |
Thr41 |
GIHSGATtTAPSLSG |
Homo sapiens |
|
| pmid |
sentence |
| 11955436 |
Wnt regulation of beta-catenin degradation is essential for development and carcinogenesis. beta-catenin degradation is initiated upon amino-terminal serine/threonine phosphorylation, which is believed to be performed by glycogen synthase kinase-3 (GSK-3) in complex with tumor suppressor proteins Axin and adnomatous polyposis coli (APC). |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260016 |
Thr41 |
GIHSGATtTAPSLSG |
in vitro |
|
| pmid |
sentence |
| 11955436 |
β-catenin degradation is initiated upon amino-terminal serine/threonine phosphorylation, which is believed to be performed by glycogen synthase kinase-3 (GSK-3) in complex with tumor suppressor proteins Axin and adnomatous polyposis coli (APC) |
|
| Publications: |
12 |
Organism: |
Homo Sapiens, In Vitro |
| Tissue: |
Colonic Cancer Cell, Brain |
| Pathways: | Acute Myeloid Leukemia, FLT3-ITD signaling, WNT/FLT3 |
| + |
NEK2 | down-regulates quantity
phosphorylation
|
CTNNB1 |
0.477 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278173 |
Ser33 |
QQQSYLDsGIHSGAT |
Homo sapiens |
|
| pmid |
sentence |
| 30968157 |
NEK2 silencing reduced the phosphorylation of beta-catenin at Ser33 and Ser37, but did not decrease the level of total beta-catenin.|NEK2 slightly decreased the level of total beta-catenin (XREF_FIG). |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278172 |
Ser37 |
YLDSGIHsGATTTAP |
Homo sapiens |
|
| pmid |
sentence |
| 30968157 |
NEK2 silencing reduced the phosphorylation of beta-catenin at Ser33 and Ser37, but did not decrease the level of total beta-catenin.|NEK2 slightly decreased the level of total beta-catenin (XREF_FIG). |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
JNK | down-regulates
phosphorylation
|
CTNNB1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-165026 |
Ser37 |
YLDSGIHsGATTTAP |
Homo sapiens |
|
| pmid |
sentence |
| 20419129 |
Specifically, we provide evidence that jnk binds to e-cadherin/beta-catenin complex and phosphorylates beta-catenin at serine 37 and threonine 41, the sites also phosphorylated by gsk-3beta. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-187578 |
Ser37 |
YLDSGIHsGATTTAP |
Homo sapiens |
|
| pmid |
sentence |
| 19667122 |
Specifically, we provide evidence that jnk binds to e-cadherin/beta-catenin complex and phosphorylates beta-catenin at serine 37 and threonine 41, the sites also phosphorylated by gsk-3beta. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-187582 |
Thr41 |
GIHSGATtTAPSLSG |
Homo sapiens |
|
| pmid |
sentence |
| 19667122 |
Specifically, we provide evidence that jnk binds to e-cadherin/beta-catenin complex and phosphorylates beta-catenin at serine 37 and threonine 41, the sites also phosphorylated by gsk-3beta. |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| Pathways: | FLT3-ITD signaling |
| + |
CSNK1E | down-regulates
phosphorylation
|
CTNNB1 |
0.651 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-87448 |
Ser45 |
GATTTAPsLSGKGNP |
Homo sapiens |
|
| pmid |
sentence |
| 12000790 |
However, ck1epsilon has been recently shown to interact with axin (sakanaka et al. 1999;rubinfeld et al. 2001), and it was proposed that this kinase mediates axin-induced apc phosphorylation, thereby stabilizing the beta-catenin degradation complex (rubinfeld et al. 2001). We have, therefore, evaluated ck1epsilon as a candidate s45-kinase in several assays, both in vitro and in vivo. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CSNK1E | down-regulates activity
phosphorylation
|
CTNNB1 |
0.651 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-244102 |
Ser45 |
GATTTAPsLSGKGNP |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 12176352 |
Using mass spectrometry and phosphopeptide-specific antibodies, we show that a complex of axin and casein kinase I (CKI) induces Beta-catenin phosphorylation at a single site: serine 45 (S45). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PRKCZ | down-regulates quantity by destabilization
phosphorylation
|
CTNNB1 |
0.595 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276878 |
Ser45 |
GATTTAPsLSGKGNP |
Homo sapiens |
HEK-293T Cell |
| pmid |
sentence |
| 25660024 |
Yap and β-catenin are direct substrates of PKCζ. Similar MS/MS analysis to map the sites phosphorylated in β-catenin by PKCζ identified S45 and several sites of low abundance that included S552 and S675 (Figure S3C). |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276879 |
Ser552 |
QDTQRRTsMGGTQQQ |
Homo sapiens |
HEK-293T Cell |
| pmid |
sentence |
| 25660024 |
Yap and β-catenin are direct substrates of PKCζ. Similar MS/MS analysis to map the sites phosphorylated in β-catenin by PKCζ identified S45 and several sites of low abundance that included S552 and S675 (Figure S3C). |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276880 |
Ser675 |
QDYKKRLsVELTSSL |
Homo sapiens |
HEK-293T Cell |
| pmid |
sentence |
| 25660024 |
Yap and β-catenin are direct substrates of PKCζ. Similar MS/MS analysis to map the sites phosphorylated in β-catenin by PKCζ identified S45 and several sites of low abundance that included S552 and S675 (Figure S3C). |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| + |
CSNK1D | down-regulates
phosphorylation
|
CTNNB1 |
0.617 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-87441 |
Ser45 |
GATTTAPsLSGKGNP |
Homo sapiens |
|
| pmid |
sentence |
| 12000790 |
However, ckiepsilon has been recently shown to interact with axin (sakanaka et al. 1999;rubinfeld et al. 2001), and it was proposed that this kinase mediates axin-induced apc phosphorylation, thereby stabilizing the -catenin degradation complex (rubinfeld et al. 2001). We have, therefore, evaluated cki as a candidate s45-kinase in several assays, both in vitro and in vivo. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CSNK1A1L | down-regulates
phosphorylation
|
CTNNB1 |
0.499 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-87430 |
Ser45 |
GATTTAPsLSGKGNP |
Homo sapiens |
|
| pmid |
sentence |
| 12000790 |
We show that a complex of axin and casein kinase i (cki) induces beta-catenin phosphorylation at a single site: serine 45 (s45). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CyclinD1/CDK6 | down-regulates activity
phosphorylation
|
CTNNB1 |
0.641 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250647 |
Ser45 |
GATTTAPsLSGKGNP |
in vitro |
|
| pmid |
sentence |
| 17208333 |
We showed that CCND1-CDK6 phosphorylates beta-catenin on serine 45 (S45). This phosphorylation creates a priming site for glycogen synthase kinase 3beta (GSK3beta) and is both necessary and sufficient to initiate the beta-catenin phosphorylation-degradation cascade. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| Pathways: | Pancreatic ductal adenocarcinoma (PDA) |
| + |
CSNK1A1 | down-regulates
phosphorylation
|
CTNNB1 |
0.788 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-165022 |
Ser45 |
GATTTAPsLSGKGNP |
Homo sapiens |
|
| pmid |
sentence |
| 20419129 |
Specifically, ck1_ phosphorylates _-catenin at s45, which primes this n-terminal region for subsequent phosphorylations by gsk3 at t41, s37 and s33 [7]. These latter two phosphorylations are recognized by the e3-ligase component, _-trcp, for ultimate ubiquitylation and destruction by the proteosome |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Wnt in cancer, WNT Signaling, WNT/FLT3 |
| + |
AKT2 | up-regulates
phosphorylation
|
CTNNB1 |
0.565 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-152958 |
Ser552 |
QDTQRRTsMGGTQQQ |
Homo sapiens |
|
| pmid |
sentence |
| 17287208 |
Phosphorylation of beta-catenin by akt promotes beta-catenin transcriptional activitywe have demonstrated that akt phosphorylates beta-catenin at ser552 in vitro and in vivo. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CAMK2B | down-regulates
phosphorylation
|
CTNNB1 |
0.293 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-202825 |
Ser552 |
QDTQRRTsMGGTQQQ |
Homo sapiens |
|
| pmid |
sentence |
| 24117889 |
Camkii represses transcriptionally active beta-catenin to mediate acute ethanol neurodegeneration and can phosphorylate beta-catenin. Using targeted mutagenesis we identified camkii phosphorylation sites within human beta-catenin at t332, t472, and s552 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-202829 |
Thr332 |
VNIMRTYtYEKLLWT |
Homo sapiens |
Neuron |
| pmid |
sentence |
| 24117889 |
Camkii represses transcriptionally active _-catenin to mediate acute ethanol neurodegeneration and can phosphorylate _-catenincamkii can directly phosphorylate _-catenin. Using targeted mutagenesis we identified camkii phosphorylation sites within human _-catenin at t332, t472, and s552. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-202833 |
Thr472 |
ICALRHLtSRHQEAE |
Homo sapiens |
Neuron |
| pmid |
sentence |
| 24117889 |
Camkii represses transcriptionally active _-catenin to mediate acute ethanol neurodegeneration and can phosphorylate _-catenincamkii can directly phosphorylate _-catenin. Using targeted mutagenesis we identified camkii phosphorylation sites within human _-catenin at t332, t472, and s552. |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| + |
AKT1 | up-regulates
phosphorylation
|
CTNNB1 |
0.807 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252499 |
Ser552 |
QDTQRRTsMGGTQQQ |
Homo sapiens |
|
| pmid |
sentence |
| 17287208 |
Phosphorylation of beta-catenin by akt promotes beta-catenin transcriptional activity|we have demonstrated that akt phosphorylates beta-catenin at ser552 in vitro and in vivo. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | FLT3-ITD signaling |
| + |
AURKA | up-regulates quantity
phosphorylation
|
CTNNB1 |
0.352 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278468 |
Ser552 |
QDTQRRTsMGGTQQQ |
Homo sapiens |
|
| pmid |
sentence |
| 25217103 |
In addition, Aurora-A overexpression is significantly correlated with increased cytoplasmic \u03b2-catenin expression in esophageal squamous cell carcinoma tissues.|We also demonstrate for the first time that Aurora-A directly interacts with \u03b2-catenin and phosphorylates \u03b2-catenin at Ser552 and Ser675. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278469 |
Ser675 |
QDYKKRLsVELTSSL |
Homo sapiens |
|
| pmid |
sentence |
| 25217103 |
In addition, Aurora-A overexpression is significantly correlated with increased cytoplasmic \u03b2-catenin expression in esophageal squamous cell carcinoma tissues.|We also demonstrate for the first time that Aurora-A directly interacts with \u03b2-catenin and phosphorylates \u03b2-catenin at Ser552 and Ser675. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
PRKACA | up-regulates activity
phosphorylation
|
CTNNB1 |
0.466 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-144478 |
Ser552 |
QDTQRRTsMGGTQQQ |
Homo sapiens |
|
| pmid |
sentence |
| 16476742 |
In the present study, we have shown that (i) beta-catenin can be phosphorylated by protein kinase a (pka) in vitro and in intact cells at two novel sites, ser-552 and ser-675;(ii) phosphorylation by pka promotes the transcriptional activity (tcf/lef transactivation) of beta-catenin |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-144482 |
Ser675 |
QDYKKRLsVELTSSL |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 16476742 |
In the present study, we have shown that (i) beta-catenin can be phosphorylated by protein kinase a (pka) in vitro and in intact cells at two novel sites, ser-552 and ser-675;(ii) phosphorylation by pka promotes the transcriptional activity (tcf/lef transactivation) of beta-catenin |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-140902 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 16199882 |
Although pka did not affect the formation of a complex between glycogen synthase kinase 3beta (gsk-3beta), beta-catenin, and axin, phosphorylation of beta-catenin by pka inhibited ubiquitination of beta-catenin in intact cells and in vitro. |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| Pathways: | WNT Signaling, WNT/FLT3, WNT Signaling and Myogenesis |
| + |
AKT | up-regulates
phosphorylation
|
CTNNB1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-244222 |
Ser552 |
QDTQRRTsMGGTQQQ |
Homo sapiens |
|
| pmid |
sentence |
| 17287208 |
Phosphorylation of beta-catenin by akt promotes beta-catenin transcriptional activity|we have demonstrated that akt phosphorylates beta-catenin at ser552 in vitro and in vivo. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia, FLT3 in AML, FLT3-ITD in AML, FLT3-ITD signaling, Hepatocellular Tumor, Pancreatic ductal adenocarcinoma (PDA), Rhabdomyosarcoma, Thyroid cancer, WNT/FLT3 |
| + |
RPS6KA5 | up-regulates activity
phosphorylation
|
CTNNB1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278247 |
Ser552 |
QDTQRRTsMGGTQQQ |
Homo sapiens |
|
| pmid |
sentence |
| 27196759 |
Co-transfection of MSK1 increased beta-catenin transcriptional activity in a dose dependent manner (XREF_FIG).|Our in vitro kinase assay showed that MSK1 can directly phosphorylate beta-catenin at Ser 552. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PAK4 | up-regulates
phosphorylation
|
CTNNB1 |
0.292 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-191557 |
Ser675 |
QDYKKRLsVELTSSL |
Homo sapiens |
|
| pmid |
sentence |
| 22173096 |
Pak4 interacts with and phosphorylates _-catenin on ser675, which promotes the tcf/lef transcriptional activity and stabilizes _-catenin through inhibition of its degradation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PAK1 | up-regulates
phosphorylation
|
CTNNB1 |
0.555 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-175944 |
Ser675 |
QDYKKRLsVELTSSL |
Homo sapiens |
|
| pmid |
sentence |
| 21822311 |
Pak1 directly phosphorylates _-catenin proteins at ser675 site and this leads to more stable and transcriptional active _-catenin |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PRKCD | down-regulates activity
phosphorylation
|
CTNNB1 |
0.273 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260897 |
Ser715 |
GYRQDDPsYRSFHSG |
Homo sapiens |
|
| pmid |
sentence |
| 25639486 |
Moreover, protein kinase Cδ, which directly phosphorylates β-catenin at Ser715, is required for the TRIM33–β-catenin interaction. | Phosphorylation of β-catenin Ser715 is critical for TRIM33-induced β-catenin degradation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PLK1 |
phosphorylation
|
CTNNB1 |
0.402 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-182150 |
Ser718 |
QDDPSYRsFHSGGYG |
Homo sapiens |
|
| pmid |
sentence |
| 19001871 |
Ser-718 of beta-catenin was directly phosphorylated by recombinant plk1thus it may be possible that function of the additional phosphorylation site(s) in cooperation with the ser-718 is required for the regulation of _-catenin at m phase |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PRKD1 | up-regulates
phosphorylation
|
CTNNB1 |
0.399 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-183384 |
Thr112 |
EGMQIPStQFDAAHP |
Homo sapiens |
Prostate Gland Cancer Cell |
| pmid |
sentence |
| 19141652 |
This study provides evidence that pkd1 interacts with and phosphorylates beta-catenin at thr(112) and thr(120) we postulate that pkd1 phosphorylation is required to maintain _-catenin transcription activity. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-183388 |
Thr120 |
QFDAAHPtNVQRLAE |
Homo sapiens |
Prostate Gland Cancer Cell |
| pmid |
sentence |
| 19141652 |
This study provides evidence that pkd1 interacts with and phosphorylates beta-catenin at thr(112) and thr(120) we postulate that pkd1 phosphorylation is required to maintain _-catenin transcription activity. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
STK26 | up-regulates quantity by stabilization
phosphorylation
|
CTNNB1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280141 |
Thr40 |
SGIHSGAtTTAPSLS |
Homo sapiens |
|
| pmid |
sentence |
| 34240584 |
In response to Wnt3a stimulation, the kinase MST4 directly phosphorylates \u03b2-catenin at Thr40 to block its Ser33 phosphorylation by GSK3\u03b2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PTK2 |
phosphorylation
|
CTNNB1 |
0.415 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261946 |
Tyr142 |
AVVNLINyQDDAELA |
Mus musculus |
|
| pmid |
sentence |
| 22264731 |
VEGF promotes tension-independent FAK activation, rapid FAK localization to cell-cell junctions, binding of the FAK FERM domain to the vascular endothelial cadherin (VE-cadherin) cytoplasmic tail, and direct FAK phosphorylation of β-catenin at tyrosine-142 (Y142) facilitating VE-cadherin-β-catenin dissociation and EC junctional breakdown. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
PTK6 | down-regulates quantity
phosphorylation
|
CTNNB1 |
0.308 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278286 |
Tyr142 |
AVVNLINyQDDAELA |
Homo sapiens |
|
| pmid |
sentence |
| 20026641 |
PTK6 directly phosphorylates beta-catenin on Tyr64, Tyr142, Tyr331 and/or Tyr333, with the predominant site being Tyr64.|The ability of PTK6 to negatively regulate beta-catenin and TCF transcription by modulating levels of TCF4 and TLE and Groucho could contribute to its growth-inhibitory activities in vivo. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278287 |
Tyr331 |
LVNIMRTyTYEKLLW |
Homo sapiens |
|
| pmid |
sentence |
| 20026641 |
PTK6 directly phosphorylates beta-catenin on Tyr64, Tyr142, Tyr331 and/or Tyr333, with the predominant site being Tyr64.|The ability of PTK6 to negatively regulate beta-catenin and TCF transcription by modulating levels of TCF4 and TLE and Groucho could contribute to its growth-inhibitory activities in vivo. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278289 |
Tyr333 |
NIMRTYTyEKLLWTT |
Homo sapiens |
|
| pmid |
sentence |
| 20026641 |
PTK6 directly phosphorylates beta-catenin on Tyr64, Tyr142, Tyr331 and/or Tyr333, with the predominant site being Tyr64.|The ability of PTK6 to negatively regulate beta-catenin and TCF transcription by modulating levels of TCF4 and TLE and Groucho could contribute to its growth-inhibitory activities in vivo. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278288 |
Tyr64 |
VDTSQVLyEWEQGFS |
Homo sapiens |
|
| pmid |
sentence |
| 20026641 |
PTK6 directly phosphorylates beta-catenin on Tyr64, Tyr142, Tyr331 and/or Tyr333, with the predominant site being Tyr64.|The ability of PTK6 to negatively regulate beta-catenin and TCF transcription by modulating levels of TCF4 and TLE and Groucho could contribute to its growth-inhibitory activities in vivo. |
|
| Publications: |
4 |
Organism: |
Homo Sapiens |
| + |
NTRK1 | up-regulates activity
phosphorylation
|
CTNNB1 |
0.424 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279240 |
Tyr142 |
AVVNLINyQDDAELA |
Homo sapiens |
|
| pmid |
sentence |
| 22558232 |
EGFR and TRKA effect on WNT3a mediated Topflash induction was abolished by U0126 or expression of dominant negative LRP6-5A mutant (XREF_FIG), demonstrating that both EGFR and TRKA signal via ERK and LRP6 pathway to upregulate WNT and beta-catenin signaling.|FGFR2, FGFR3, EGFR and TRKA Phosphorylate \u03b2-catenin at Tyr142. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
EGFR | up-regulates activity
phosphorylation
|
CTNNB1 |
0.773 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278309 |
Tyr142 |
AVVNLINyQDDAELA |
Homo sapiens |
|
| pmid |
sentence |
| 22558232 |
EGFR and TRKA effect on WNT3a mediated Topflash induction was abolished by U0126 or expression of dominant negative LRP6-5A mutant (XREF_FIG), demonstrating that both EGFR and TRKA signal via ERK and LRP6 pathway to upregulate WNT and beta-catenin signaling.|FGFR2, FGFR3, EGFR and TRKA Phosphorylate beta-catenin at Tyr142. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278308 |
Tyr654 |
RNEGVATyAAAVLFR |
Homo sapiens |
|
| pmid |
sentence |
| 25164010 |
One possible explanation is that activation of \u03b2-catenin by EGFR mutants may \u201cprime\u201d pulmonary cells to be susceptible to other downstream signaling aberrations and subsequent transformation into tumor cells.|beta-catenin is phosphorylated at Y86 by Src and oncogenic Bcr-Abl and at Y654 by activated wild type EGFR and oncogenic FLT3-ITD. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia, FLT3-ITD in AML, Hepatocellular Tumor, Pancreatic ductal adenocarcinoma (PDA) |
| + |
FYN | down-regulates activity
phosphorylation
|
CTNNB1 |
0.843 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251162 |
Tyr142 |
AVVNLINyQDDAELA |
in vitro |
|
| pmid |
sentence |
| 12640114 |
Interaction of beta-catenin with alpha-catenin is regulated by the phosphorylation of beta-catenin Tyr-142. This residue can be phosphorylated in vitro by Fer or Fyn tyrosine kinases. Transfection of these kinases to epithelial cells disrupted the association between both catenins. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
FER | down-regulates activity
phosphorylation
|
CTNNB1 |
0.704 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251131 |
Tyr142 |
AVVNLINyQDDAELA |
in vitro |
|
| pmid |
sentence |
| 12640114 |
Interaction of beta-catenin with alpha-catenin is regulated by the phosphorylation of beta-catenin Tyr-142. This residue can be phosphorylated in vitro by Fer or Fyn tyrosine kinases. Transfection of these kinases to epithelial cells disrupted the association between both catenins. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
JAK3 | up-regulates activity
phosphorylation
|
CTNNB1 |
0.455 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278178 |
Tyr30 |
SHWQQQSyLDSGIHS |
Homo sapiens |
|
| pmid |
sentence |
| 28821617 |
Jak3 phosphorylates Tyr 30, Tyr 64, and Tyr 86 of beta-catenin in intestinal epithelial cells. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278179 |
Tyr64 |
VDTSQVLyEWEQGFS |
Homo sapiens |
|
| pmid |
sentence |
| 28821617 |
Jak3 phosphorylates Tyr 30, Tyr 64, and Tyr 86 of beta-catenin in intestinal epithelial cells. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278180 |
Tyr86 |
VADIDGQyAMTRAQR |
Homo sapiens |
|
| pmid |
sentence |
| 28821617 |
Jak3 phosphorylates Tyr 30, Tyr 64, and Tyr 86 of beta-catenin in intestinal epithelial cells. |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| + |
SRC | up-regulates
phosphorylation
|
CTNNB1 |
0.76 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-177086 |
Tyr333 |
NIMRTYTyEKLLWTT |
Homo sapiens |
|
| pmid |
sentence |
| 22056988 |
Egfr activation induces translocation of pkm2 into the nucleus, where k433 of pkm2 binds to c-src-phosphorylated y333 of _-cateninthese findings reveal that egf induces _-catenin transactivation via a mechanism distinct from that induced by wnt/wingless and highlight the essential non-metabolic functions of pkm2 in egfr-promoted _-catenin transactivation, cell proliferation and tumorigenesis |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Rhabdomyosarcoma |
| + |
PTPN6 | down-regulates quantity by destabilization
dephosphorylation
|
CTNNB1 |
0.546 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277014 |
Tyr654 |
RNEGVATyAAAVLFR |
Homo sapiens |
|
| pmid |
sentence |
| 20840866 |
Because SHP-1 can dephosphorylate residues Y86 and Y654 on the \u03b2-catenin protein, these residues were therefore mutated into phenylalanine and the transcriptional activity of the subsequent \u03b2-catenin mutants analyzed: \u03b2-catenin/Y86F, \u03b2-catenin/Y654F and \u03b2-catenin/Y86F/Y654F. As shown in Fig.\u00a03 B, the mutants \u03b2-catenin/Y86F, \u03b2-catenin/Y654F and \u03b2-catenin/Y86F/Y654F had a significantly reduced transcriptional activity in comparison to wild-type \u03b2-catenin.|SHP-1 inhibits \u03b2-catenin function by inducing its degradation and interfering with its association with TATA-binding protein. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277013 |
Tyr86 |
VADIDGQyAMTRAQR |
Homo sapiens |
|
| pmid |
sentence |
| 20840866 |
In the present investigation, we demonstrate that SHP-1 dephosphorylates \u03b2-catenin on tyrosines 86 and 654 and promotes its proteasomal degradation.|SHP-1 inhibits \u03b2-catenin function by inducing its degradation and interfering with its association with TATA-binding protein. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia, FLT3 in AML, FLT3-ITD in AML |
| + |
ERBB2 | down-regulates activity
phosphorylation
|
CTNNB1 |
0.765 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279041 |
Tyr654 |
RNEGVATyAAAVLFR |
Homo sapiens |
|
| pmid |
sentence |
| 23576562 |
Second, ErbB2 phosphorylates \u03b2-catenin at Tyr 654, leading to dissociation of the E-cadherin-\u03b2-catenin membrane complex and increased signaling to Wnt target genes such as cyclin D1 ( ). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Colorectal Carcinoma |
| + |
BCR-ABL | up-regulates
phosphorylation
|
CTNNB1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-153431 |
Tyr654 |
RNEGVATyAAAVLFR |
Homo sapiens |
Leukemia Cell |
| pmid |
sentence |
| 17318191 |
Bcr-abl stabilizes beta-catenin in chronic myeloid leukemia through its tyrosine phosphorylationthe notion that y86 and y654 are located respectively within the n_ and c_terminal transcriptional domains of __catenin suggests that one or both residues might regulate the transactivating function of __catenin. In this regard, phosphorylation of y654 was reported to strengthen __catenin association with the basal transcription factor tata_binding protein (tbp) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia, Onco-fusion proteins in AML |
| + |
SRC | up-regulates activity
phosphorylation
|
CTNNB1 |
0.76 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-106454 |
Tyr654 |
RNEGVATyAAAVLFR |
Homo sapiens |
|
| pmid |
sentence |
| 11279024 |
Beta-catenin is a good substrate of pp60c- src tyrosine kinase in vitro;this kinase modifies specifically tyr-86 and tyr-654,although consistently detected, this negative effect of tyr-86 phosphorylation on tbp binding was clearly less important than the positive effect observed after tyr-654 phosphorylation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Rhabdomyosarcoma |
| + |
BCR-ABL | down-regulates
phosphorylation
|
CTNNB1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-153435 |
Tyr86 |
VADIDGQyAMTRAQR |
Homo sapiens |
Leukemia Cell |
| pmid |
sentence |
| 17318191 |
Bcr_abl_mediated phosphorylation of y86 could induce a conformational change of __catenin impairing its binding to axin |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia, Onco-fusion proteins in AML |
| + |
SRC | down-regulates activity
phosphorylation
|
CTNNB1 |
0.76 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-106458 |
Tyr86 |
VADIDGQyAMTRAQR |
Homo sapiens |
SW-480 Cell |
| pmid |
sentence |
| 11279024 |
beta-catenin is a good substrate of pp60c- srctyrosine kinase in vitro;this kinase modifies specifically tyr-86 and tyr-654although consistently detected, this negative effect of tyr-86 phosphorylation on tbp binding was clearly less important than the positive effect observed after tyr-654 phosphorylation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Rhabdomyosarcoma |
| + |
CTNNB1 | up-regulates activity
binding
|
LEF1 |
0.915 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-169632 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21078818 |
Phosphorylated lrp5/6 leads to inhibition of the so-called beta-catenin destruction complex (which includes axin, gsk3, dvl, ck1, and the tumor suppressor adenomatous polyposis coli), resulting in the stabilization and translocation of beta-catenin in the nucleus, where it activates target genes through binding to tcf/lef transcription factors. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-134219 |
|
|
Homo sapiens |
T-lymphocyte |
| pmid |
sentence |
| 15735151 |
Activated dvl binds and inhibits the phosphorylation of beta catenin by gsk3beta/alfa, blocking beta catenin degradation), so that beta catenin accumulates and translocates to the nucleus, where it interacts with the t cell specific factor (tcf)/lymphoid enhancer binding factor 1 (lef-1) transcription factor and induces the transcription of target genes such as c-jun, c-myc, and cyclin d1 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-199378 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23151663 |
Upon wnt activation, cytoplasmic beta-catenin is stabilized and enters the nucleus, where it associates with transcription factors, notably tcf (t cell factor) and lef (lymphoid enhancer-binding factor), to regulate the transcription of target genes. Thus beta-catenin regulates gene expression by direct interaction with transcription factors such as lef-1, providing a molecular mechanism for the transmission of signals, from cell-adhesion components or wnt protein to the nucleus. |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| Pathways: | Colorectal Carcinoma, Hepatocellular Tumor, Wnt in cancer, WNT Signaling, WNT/FLT3, WNT Signaling and Myogenesis |
| + |
CDH16 | up-regulates activity
binding
|
CTNNB1 |
0.365 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265855 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21255999 |
At its C-terminus, cadherin interacts with β-catenin, which dynamically associates with α-catenin, a direct binding partner of filamentous actin |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PTPRJ | up-regulates activity
dephosphorylation
|
CTNNB1 |
0.506 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276992 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25386896 |
Our data demonstrate that CD148 promotes E-cadherin cell adhesion by regulating Rac1 activity, concomitant with modulation of p120, \u03b2-catenin, and Src tyrosine phosphorylation, and that this effect requires E-cadherin and p120 association.|Taken together, it is likely that CD148 dephosphorylation of \u03b2-catenin enhances the cadherin cell adhesion independent of Rho family GTPases. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia, FLT3-ITD in AML |
| + |
CTNNB1 | up-regulates activity 
|
Metastasis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256534 |
|
|
Mus musculus |
Mammary Gland Tumor Cell Line |
| pmid |
sentence |
| 17420453 |
Overexpression of ERp5 promotes both in vitro migration and invasion and in vivo metastasis of breast cancer cells. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
PSEN1 | down-regulates
binding
|
CTNNB1 |
0.809 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-22837 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 2195779 |
Importantly, our data show that binding of ps1 to cadherin mediates the effects of ps1 on the phosphorylation, ubiquitination, and destabilization of beta-catenin. Thus, cadherins mediate both the association of ps1 and beta-catenin and the effects of ps1 on the cellular levels of beta-catenin |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CDH13 | up-regulates activity
binding
|
CTNNB1 |
0.525 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265853 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21255999 |
At its C-terminus, cadherin interacts with β-catenin, which dynamically associates with α-catenin, a direct binding partner of filamentous actin |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PTPRU | down-regulates activity
dephosphorylation
|
CTNNB1 |
0.404 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277095 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25337216 |
Protein tyrosine phosphatase receptor U (PTPRU) has been shown to be a tumor suppressor in colon cancer by dephosphorylating \u03b2-catenin and reducing the activation of \u03b2-catenin signaling. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CTNNB1 | down-regulates activity
binding
|
YAP/TAZ |
0.541 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277656 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24976009 |
YAP/TAZ Are Transcriptionally Inactivated by Sequestration in the Destruction Complex. YAP and TAZ Are Sequestered in the Cytoplasm by the β-Catenin Destruction Complex. This analysis revealed that Axin1 not only bound established elements of the destruction complex (such as GSK3β, β-catenin and β-TrCP) but, remarkably, also strongly associated to endogenous YAP and TAZ (Figure 1A). To further confirm YAP/TAZ association to the destruction complex, we carried out immunoprecipitations for endogenous YAP/TAZ from extracts of control or Axin1/2-depleted HEK293 cells. As shown in Figure 1B, YAP and TAZ associate with endogenous Axin1, β-catenin, GSK3, and β-TrCP. mplex |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CTNNB1 | up-regulates quantity by expression
transcriptional regulation
|
AFF3 |
0.287 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259192 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 26214578 |
We demonstrate that AFF3 is a new target of Wnt/β-catenin pathway involved in ACC, acting on transcription and RNA splicing. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CDH2 | up-regulates activity
binding
|
CTNNB1 |
0.818 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265864 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21255999 |
At its C-terminus, cadherin interacts with β-catenin, which dynamically associates with α-catenin, a direct binding partner of filamentous actin |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CTNNB1 | up-regulates activity
|
H3C1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260448 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16510874 |
Beta-cat promotes h3k4 trimethylation at the c-myc gene in vivo. H3k4 trimethylation in vivo requires prior ubiquitination of h2b, and we find that ubiquitin is necessary for transcription initiation on chromatin but not nonchromatin templates in vitro. Chromatin immunoprecipitation experiments reveal that beta-cat recruits pygopus, bcl-9/legless, and mll/set1-type complexes to the c-myc enhancertogether with the negative wnt regulators, apc, and betatrcp. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CDH1 | up-regulates activity
binding
|
CTNNB1 |
0.959 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265863 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21255999 |
At its C-terminus, cadherin interacts with β-catenin, which dynamically associates with α-catenin, a direct binding partner of filamentous actin |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MYH9 | up-regulates quantity by expression
transcriptional regulation
|
CTNNB1 |
0.277 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269284 |
|
|
Homo sapiens |
MGC-803 Cell |
| pmid |
sentence |
| 32685004 |
Nuclear MYH9 bound to the CTNNB1 promoter through its DNA-binding domain, and interacted with myosin light chain 9, β-actin and RNA polymerase II to promote CTNNB1 transcription, which conferred resistance to anoikis in GC cells in vitro and in vivo. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278896 |
|
|
Homo sapiens |
Gastric Cancer Cell |
| pmid |
sentence |
| 32685004 |
Nuclear MYH9 bound to the CTNNB1 promoter through its DNA-binding domain, and interacted with myosin light chain 9, β-actin and RNA polymerase II to promote CTNNB1 transcription, which conferred resistance to anoikis in GC cells in vitro and in vivo. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
CTNNB1 | up-regulates activity
binding
|
α-Catenin |
0.922 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265813 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21255999 |
At its C-terminus, cadherin interacts with β-catenin, which dynamically associates with α-catenin, a direct binding partner of filamentous actin |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
APC2 | down-regulates quantity by destabilization
relocalization
|
CTNNB1 |
0.784 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-81545 |
|
|
Homo sapiens |
SW-480 Cell |
| pmid |
sentence |
| 10980707 |
The tumour-suppressing activity of apc largely involves facilitating the proteasome-mediated degradation of b-cateninit is possible that once exported from the nucleus, apc directs b-catenin along the cytoskeletal network to sites of degradation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SIRT1 | up-regulates quantity
deacetylation
|
CTNNB1 |
0.516 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256208 |
|
|
Mus musculus |
MEF Cell |
| pmid |
sentence |
| 27776347 |
SIRT1 deacetylates β-catenin to promote its accumulation in the nucleus and thus induces the transcription of genes that block MSC adipogenesis. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Acute Myeloid Leukemia, FLT3-ITD in AML |
| + |
CDH15 | up-regulates activity
binding
|
CTNNB1 |
0.626 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265854 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21255999 |
At its C-terminus, cadherin interacts with β-catenin, which dynamically associates with α-catenin, a direct binding partner of filamentous actin |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CDH3 | up-regulates activity
binding
|
CTNNB1 |
0.845 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265865 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21255999 |
At its C-terminus, cadherin interacts with β-catenin, which dynamically associates with α-catenin, a direct binding partner of filamentous actin |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
AXIN2 | down-regulates
binding
|
CTNNB1 |
0.848 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-79947 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10911903 |
It has been found that a multiprotein complex assembled by the cytoplasmic component conductin induces degradation of cytoplasmic beta-catenin. The complex includes apc, the serine/threonine kinase gsk3 beta, and beta-catenin, which bind to conductin at distinct domains. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Brain, Kidney, Lung |
| + |
CTNNB1 | up-regulates quantity by expression
transcriptional regulation
|
CCND1 |
0.802 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277738 |
|
|
Homo sapiens |
PANC-1 Cell |
| pmid |
sentence |
| 30519351 |
One of the most well studied activators of CCND1 transcription is β-catenin, which could be actived by AKT signalling to inducing G1/S transition. When β-catenin is translocated from the cytoplasm to the nucleus, it forms a complex with the ternary complex factor (TCF) and/or lymphoid enhancer-binding factor (LEF) and stimulates cyclin D1 gene transcription (Fig. 4C).In agreement with the data described above, a chromatin immunoprecipitation (ChIP) assay confirmed that TNC regulates the binding of β-catenin to the TCF/LEF-binding site in the CCND1 promoter (Fig. 4C). Additionally, the β-cateninbinding activity with respect to the CCND1 promoter was much higher in TNC-overexpression PANC-1 cells than in the vector controls. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia |
| + |
AKT2 | up-regulates activity
|
CTNNB1 |
0.565 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-141655 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16293724 |
We show that pge2 stimulates colon cancer cell growth through its heterotrimeric guanine nucleotide-binding protein (g protein) coupled receptor, ep2, by a signaling route that involves the activation of phosphoinositide 3-kinase and the protein kinase akt by free g protein bg subunits and the direct association of the g protein as subunit with the regulator of g protein signaling (rgs) domain of axin. This leads to the inactivation and release of glycogen synthase kinase 3b from its complex with axin, thereby relieving the inhibitory phosphorylation of b-catenin and activating its signaling pathway. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ADNP | up-regulates quantity by stabilization
binding
|
CTNNB1 |
0.252 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266756 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 32533114 |
Here, we show that ADNP is required for neural induction and differentiation by enhancing Wnt signaling. Mechanistically, ADNP functions to stabilize β-Catenin through binding to its armadillo domain which prevents its association with key components of the degradation complex: Axin and APC. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CDH6 | up-regulates activity
binding
|
CTNNB1 |
0.567 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265868 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21255999 |
At its C-terminus, cadherin interacts with β-catenin, which dynamically associates with α-catenin, a direct binding partner of filamentous actin |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SCF-betaTRCP | down-regulates
ubiquitination
|
CTNNB1 |
0.72 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-217181 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10023660 |
These results indicate that the cul1/skp1/beta-trcp complex forms a ubiquitin ligase that mediates the degradation of beta-catenin. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SOX17 | down-regulates activity 
|
CTNNB1 |
0.682 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269268 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 33083751 |
Sox17 prevents beta-catenin activation by increasing its phosphorylation, particularly in WM lesions |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
CTNNB1 | up-regulates
|
Proliferation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255654 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18697834 |
we showed that β-catenin, a key component of the canonical Wnt-signalling cascade, is present in quiescent satellite cells in the inactive form, but subsequently becomes activated following satellite-cell activation. This observation suggests that the proliferation initiated by the Wnt-signalling cascade does not have to rely on transcription of β-catenin, but rather on activation of this protein, which is already present within the quiescent satellite cells. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255695 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23645839 |
For example, prostaglandin E2 (PGE2), 1 of the major metabolites downstream of both COX-1 and COX-2, has been shown to activate β-catenin–dependent signaling in hematopoietic stem cells (HSCs) and promote HSC expansion |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia, AML1-ETO in AML, FLT3 in AML, Onco-fusion proteins in AML, Colorectal Carcinoma, FLT3-ITD in AML, FLT3-ITD signaling, Hepatocellular Tumor, Pancreatic ductal adenocarcinoma (PDA), PPARgamma in cancer, Retinoic acid Signaling, Rhabdomyosarcoma, Thyroid cancer, Wnt in cancer, WNT Signaling, WNT/FLT3 |
| + |
WNT6 | up-regulates
|
CTNNB1 |
0.474 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-176193 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21872687 |
We show that knockdown of Beta-catenin completely prevents the inhibition of adipogenesis and stimulation of osteoblast differentiation by wnt6, wnt10a or wnt10b |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
BCL9 | up-regulates
binding
|
CTNNB1 |
0.936 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-116552 |
|
|
Homo sapiens |
B-lymphocyte |
| pmid |
sentence |
| 11955446 |
Bcl9 exert its function by physically linking pygo to beta-catenin. The recruitment of pygo permits beta-catenin to transcriptionally activate wnt target genes. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-126059 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15208637 |
The transcriptional activity of beta-catenin depends on bcl-9. Bcl-9 functions in targeting beta-catenin to the nucleus and thus increases the transcriptional activity of beta-catenin |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
CDC73 | up-regulates
binding
|
CTNNB1 |
0.69 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-146282 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16630820 |
Parafibromin/hyrax activates wnt/wg target gene transcription by direct association with beta-catenin/armadillo |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
prostaglandin E2(1-) | up-regulates
|
CTNNB1 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255685 |
|
|
Homo sapiens |
Hematopoietic Stem Cell |
| pmid |
sentence |
| 23645839 |
Prostaglandin E2 (PGE2), 1 of the major metabolites downstream of both COX-1 and COX-2, has been shown to activate β-catenin–dependent signaling in hematopoietic stem cells (HSCs) and promote HSC expansion |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia, AML1-ETO in AML |
| + |
CDH23 | up-regulates activity
binding
|
CTNNB1 |
0.289 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265861 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21255999 |
At its C-terminus, cadherin interacts with β-catenin, which dynamically associates with α-catenin, a direct binding partner of filamentous actin |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SOX4 | up-regulates activity
binding
|
CTNNB1 |
0.59 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256138 |
|
|
Homo sapiens |
SW-480 Cell |
| pmid |
sentence |
| 17875931 |
We have demonstrated that Sox17 and Sox4 can directly interact with β-catenin and TCF/LEF proteins.Sox4 enhances β-catenin/TCF activity and the proliferation of SW480 cells.In contrast, Sox4 may function to stabilize β-catenin protein. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256139 |
|
|
Homo sapiens |
Pro-B-lymphocyte |
| pmid |
sentence |
| 24970928 |
The findings in this study raise the possibility that Sox4 may also antagonize Lef1 (Tcf1 is not expressed in pro-B lymphocytes) function by controlling the stability of β-catenin in pro-B lymphocytes. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia, AML1-ETO in AML, FLT3 in AML |
| + |
CDH4 | up-regulates activity
binding
|
CTNNB1 |
0.517 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265866 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21255999 |
At its C-terminus, cadherin interacts with β-catenin, which dynamically associates with α-catenin, a direct binding partner of filamentous actin |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CDH10 | up-regulates activity
binding
|
CTNNB1 |
0.574 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265850 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21255999 |
At its C-terminus, cadherin interacts with β-catenin, which dynamically associates with α-catenin, a direct binding partner of filamentous actin |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CTNNB1 | up-regulates activity
binding
|
SCRIB |
0.434 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265826 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 21255999 |
Cadherins mediate the localization of vesicles to presynaptic compartments through multiple mechanisms. Cadherin-bound β-catenin then recruits scribble (Scrib) which acts as a scaffold for the further recruitment of proteins that mediate the localization of SVs. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Neurotransmitters release |
| + |
SOX17 | down-regulates
binding
|
CTNNB1 |
0.682 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-72006 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10549281 |
Two additional sox proteins, xsox17alfa and xsox3 , likewise bind to beta-catenin and inhibit its tcf-mediated signaling activity |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CDH17 | up-regulates activity
binding
|
CTNNB1 |
0.706 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265856 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21255999 |
At its C-terminus, cadherin interacts with β-catenin, which dynamically associates with α-catenin, a direct binding partner of filamentous actin |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CDH19 | up-regulates activity
binding
|
CTNNB1 |
0.318 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265858 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21255999 |
At its C-terminus, cadherin interacts with β-catenin, which dynamically associates with α-catenin, a direct binding partner of filamentous actin |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SOX6 | down-regulates quantity by destabilization
binding
|
CTNNB1 |
0.649 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255825 |
|
|
Homo sapiens |
Mesenchymal Stem Cell |
| pmid |
sentence |
| 26893351 |
In adipocytes, in addition to the direct regulation of PPARγ andC/EBP expression, we showed that SOX6 inhibitsWNT signaling by binding to β-catenin, potentially leading to its degradation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CDH12 | up-regulates activity
binding
|
CTNNB1 |
0.499 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265852 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21255999 |
At its C-terminus, cadherin interacts with β-catenin, which dynamically associates with α-catenin, a direct binding partner of filamentous actin |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CDH8 | up-regulates activity
binding
|
CTNNB1 |
0.672 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265870 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21255999 |
At its C-terminus, cadherin interacts with β-catenin, which dynamically associates with α-catenin, a direct binding partner of filamentous actin |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Wnt | up-regulates quantity by stabilization
|
CTNNB1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256240 |
|
|
|
|
| pmid |
sentence |
| 17081971 |
The central player in the canonical Wnt cascade is β-catenin, a cytoplasmic protein whose stability is regulated by the destruction complex. |
|
| Publications: |
1 |
| Pathways: | Hepatocellular Tumor, Wnt in cancer, WNT Signaling, WNT/FLT3, WNT Signaling and Myogenesis |
| + |
CDH5 | up-regulates activity
binding
|
CTNNB1 |
0.759 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265867 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21255999 |
At its C-terminus, cadherin interacts with β-catenin, which dynamically associates with α-catenin, a direct binding partner of filamentous actin |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CTNNB1 | down-regulates activity
|
Histone H3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265358 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16510874 |
Beta-cat promotes h3k4 trimethylation at the c-myc gene in vivo. H3k4 trimethylation in vivo requires prior ubiquitination of h2b, and we find that ubiquitin is necessary for transcription initiation on chromatin but not nonchromatin templates in vitro. Chromatin immunoprecipitation experiments reveal that beta-cat recruits pygopus, bcl-9/legless, and mll/set1-type complexes to the c-myc enhancertogether with the negative wnt regulators, apc, and betatrcp. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
WNT10A | up-regulates
|
CTNNB1 |
0.478 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-176187 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21872687 |
We show that knockdown of Beta-catenin completely prevents the inhibition of adipogenesis and stimulation of osteoblast differentiation by wnt6, wnt10a or wnt10b |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NKX2-5 | down-regulates quantity by repression
transcriptional regulation
|
CTNNB1 |
0.353 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253653 |
|
|
Homo sapiens |
Cardiac Muscle Cell Line |
| pmid |
sentence |
| 19479054 |
Using antisense inhibition we disrupted the expression of NKX2-5 and studied changes in expression of cardiac-associated genes. Down-regulation of NKX2-5 resulted in increased beta-catenin while GATA4 was decreased. We demonstrated that this regulation was conferred by binding of NKX2-5 to specific elements (NKEs) in the promoter region of the beta-catenin and GATA4 genes. Using promoter-luciferase reporter assay combined with mutational analysis of the NKEs we demonstrated that the identified NKX2-5 binding sites were essential for the suppression of beta-catenin, and upregulation of GATA4 by NKX2-5. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CTNNB1 | up-regulates
|
RUNX2 |
0.456 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-183532 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19175684 |
In-teractions between beta-catenin and runx2 play an im-portant role in bmp-9-induced osteogenic differentia-tion of mscs. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-195570 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22298955 |
In-teractions between beta-catenin and runx2 play an im-portant role in bmp-9-induced osteogenic differentia-tion of mscs. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
CTNNB1 | up-regulates activity
binding
|
TCF4 |
0.683 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-178042 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 11713476 |
beta-catenin interacts with the TCF/Lef family transcription factors. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Hepatocellular Tumor, WNT/FLT3 |
| + |
AMER1 | down-regulates activity
binding
|
CTNNB1 |
0.769 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-217950 |
|
|
Homo sapiens |
HEK-293 Cell, SW-480 Cell |
| pmid |
sentence |
| 21498506 |
We show that Amer1 binds directly to beta-catenin via a novel interaction motif, the REA repeats. This amino acid motif, including the core sequence arginine, glutamic acid and alanine, and this REA repeats mediate binding of Amer1 to the armadillo repeats of beta-catenin. The data suggest that Amer1 exerts its negative regulatory role in Wnt signaling by acting as a scaffold protein for the beta-catenin destruction complex and promoting stabilization of Axin at the plasma membrane. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CTNNB1 | up-regulates quantity by expression
transcriptional regulation
|
MYC |
0.747 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-19153 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16510874 |
Beta-cat promotes h3k4 trimethylation at the c-myc gene in vivo. H3k4 trimethylation in vivo requires prior ubiquitination of h2b, and we find that ubiquitin is necessary for transcription initiation on chromatin but not nonchromatin templates in vitro.Chromatin Immunoprecipitation experiments reveal that beta-cat recruits pygopus, bcl-9/legless, and mll/set1-type complexes to the c-myc enhancertogether with the negative wnt regulators, apc, and betatrcp. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia, AML1-ETO in AML, FLT3 in AML, Colorectal Carcinoma, FLT3-ITD in AML, FLT3-ITD signaling, Hepatocellular Tumor, Rhabdomyosarcoma, Thyroid cancer, Wnt in cancer, WNT Signaling, WNT/FLT3 |
| + |
CDH18 | up-regulates activity
binding
|
CTNNB1 |
0.565 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265857 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21255999 |
At its C-terminus, cadherin interacts with β-catenin, which dynamically associates with α-catenin, a direct binding partner of filamentous actin |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CTNNB1 | up-regulates activity
binding
|
KLF4 |
0.684 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-242100 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 24482235 |
The interaction of Beta-catenin with Tcf is important for Beta-catenin s's function in iPSCs induction. In addition, Beta-catenin interacts with Oct4, Sox2, and Klf4, respectively. In the reprogramming process, Beta-catenin further enhances expression of pluripotency-related genes. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
DAB2IP | down-regulates quantity
relocalization
|
CTNNB1 |
0.301 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254755 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 20080667 |
DAB2IP prevents β-catenin nuclear translocation. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
CDH22 | up-regulates activity
binding
|
CTNNB1 |
0.336 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265860 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21255999 |
At its C-terminus, cadherin interacts with β-catenin, which dynamically associates with α-catenin, a direct binding partner of filamentous actin |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CDH11 |
binding
|
CTNNB1 |
0.646 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-64862 |
|
|
Homo sapiens |
Breast Cancer Cell |
| pmid |
sentence |
| 10029089 |
Cadherin-11 is localized to a detergent-soluble pool and is associated with both alpha- and beta-catenin |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FASN | up-regulates quantity by stabilization
|
CTNNB1 |
0.272 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-242878 |
|
|
Homo sapiens |
Prostate Gland Cancer Cell |
| pmid |
sentence |
| 18838960 |
Overexpression of fatty acid synthase is associated with palmitoylation of Wnt1 and cytoplasmic stabilization of beta-catenin in prostate cancer |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CTNNB1 | up-regulates quantity by expression
transcriptional regulation
|
FOXA2 |
0.455 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-198929 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22945641 |
Our study indicates that beta-catenin regulates foxa2 expression, and this interaction is possibly essential to control cell cycle progression during endometrial hyperplasia formation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CTNNB1 | down-regulates activity
binding
|
PPARG |
0.55 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256072 |
|
|
Mus musculus |
Corneal Fibroblast Cell Line |
| pmid |
sentence |
| 16847334 |
Oncogenic beta-catenin resists proteasomal degradation by inhibiting PPARgamma activity, which requires its TCF/LEF binding domain |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | PPARgamma in cancer, Thyroid cancer |
| + |
CTNNBIP1 | down-regulates
binding
|
CTNNB1 |
0.806 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-79399 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10898789 |
We identify a novel beta-catenin-interacting protein, icat, that was found to inhibit the interaction of beta-catenin with tcf-4 and represses beta-catenin-tcf-4-mediated transactivation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CTNNA3 | up-regulates quantity
relocalization
|
CTNNB1 |
0.749 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265493 |
|
|
Homo sapiens |
Colonic Cancer Cell |
| pmid |
sentence |
| 21598020 |
Overexpression of CTNNA3 in a CTNNA1 negative colon carcinoma cell line resulted in the reassembly of the adherens and tight junctions through the recruitment of CTNNA3 interacting partners such as E-cadherin, β-catenin, plakoglobin, and ZO-14 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CDH9 | up-regulates activity
binding
|
CTNNB1 |
0.574 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265871 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21255999 |
At its C-terminus, cadherin interacts with β-catenin, which dynamically associates with α-catenin, a direct binding partner of filamentous actin |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CBY1 | down-regulates
binding
|
CTNNB1 |
0.687 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-100835 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12712206 |
Here we report a conserved nuclear protein, named chibby, which was identified in a screen for proteins that directly interact with the c-terminal region of beta-catenin. In mammalian cultured cells we demonstrate that chibby inhibits beta-catenin-mediated transcriptional activation by competing with lef-1 to bind to beta-catenin. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
KIT | up-regulates activity
phosphorylation
|
CTNNB1 |
0.403 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278361 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17949810 |
These results suggest that active KIT can directly phosphorylate tyrosine residues of beta-catenin. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia, Onco-fusion proteins in AML |
| + |
RXRA | down-regulates
binding
|
CTNNB1 |
0.42 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-101293 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12771132 |
Rxr agonists still inactivated endogenous beta-catenin via rxr alpha. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia, Retinoic acid Signaling |
| + |
SOX6 | down-regulates activity
binding
|
CTNNB1 |
0.649 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256073 |
|
|
Mus musculus |
3T3-L1 Cell |
| pmid |
sentence |
| 26893351 |
SOX6 interacts with β-catenin in adipocytes, suggesting an inhibition of WNT/β-catenin signaling, thereby promoting adipogenesis. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
FHIT | down-regulates
binding
|
CTNNB1 |
0.518 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-159873 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18077326 |
Fhit interacts with _-catenin in vitro and in vivo / the tumor suppressor fhit acts as a repressor of _-catenin transcriptional activity |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Pancreatic ductal adenocarcinoma (PDA) |
| + |
MST1R | up-regulates activity
phosphorylation
|
CTNNB1 |
0.332 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279376 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21423209 |
Ron and beta-catenin associate and Ron kinase activity leads to tyrosine phosphorylation of beta-catenin.|We also show that tyrosine residues 654 and 670 of beta-catenin are important in mediating Ron induced beta-catenin transcriptional activation and cell growth. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FLT3 | up-regulates activity
phosphorylation
|
CTNNB1 |
0.421 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260124 |
|
|
Homo sapiens |
Acute Myeloid Leukemia Cell |
| pmid |
sentence |
| 17851558 |
Endogenous beta-catenin co-immunoprecipitated with endogenous activated FLT3, and recombinant activated FLT3 directly phosphorylated recombinant beta-catenin. Finally, FLT3 inhibitor decreased tyrosine phosphorylation of beta-catenin in leukemia cells obtained from FLT3-ITD-positive AML patients. These data demonstrate that FLT3 activation induces beta-catenin tyrosine phosphorylation and nuclear localization, and thus suggest a mechanism for the association of FLT3 activation and beta-catenin oncogeneic signaling in AML. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia, AML1-ETO in AML, FLT3 in AML, FLT3-ITD in AML, FLT3-ITD signaling, WNT/FLT3 |
| + |
PPARG | down-regulates quantity by repression
transcriptional regulation
|
CTNNB1 |
0.55 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-164516 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20303941 |
The results from mammalian one-hybrid experiments showed that functional ppar gamma was necessary for ligand-dependent inhibition of beta-catenin transactivation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | PPARgamma in cancer, Thyroid cancer |
| + |
PAK6 | down-regulates quantity
phosphorylation
|
CTNNB1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279546 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24352566 |
Moreover, we find that \u03b2-catenin is also localized with PAK6 in cell-cell junctions and is a novel PAK6 substrate.|PAK6 binds to and phosphorylates beta-catenin. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CTNNB1 | up-regulates activity
binding
|
TCF7L2 |
0.899 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-85757 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20492721 |
Hypophosphorylation of β-catenin and translocation into the nucleus leads to binding with members of the lymphoid-enhancer-binding factor/T-cell-specific transcription factor (LEF/TCF) family and activation of WNT target genesAs a member of LEF/TCF family, transcription factor 7 like 2 (Tcf7l2, formerly called Tcf4) is an important transcription factor triggering the downstream responsive genes of WNT signaling |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CTNNB1 | up-regulates activity
binding
|
MYOD1 |
0.419 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255653 |
|
|
|
|
| pmid |
sentence |
| 18316399 |
Together, these results suggest that B-Cat increases MyoD binding to E box elements |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-161113 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18316399 |
We showed that beta-catenin interacts directly with myod, a basic helix-loop-helix transcription factor essential for muscle differentiation and enhances its binding to e box elements and transcriptional activity. |
|
| Publications: |
2 |
Organism: |
, Homo Sapiens |
| Tissue: |
Muscle |
| Pathways: | Rhabdomyosarcoma, WNT Signaling and Myogenesis |
| + |
PPP2CA | up-regulates
dephosphorylation
|
CTNNB1 |
0.454 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-182637 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19061640 |
In the absence of the wt apc protein, phosphorylated beta-catenin is rapidly dephosphorylated by serine/threonine protein phosphatase 2a (pp2a). phosphorylated beta-catenin associated with the wild-type apc protein is recruited to the scf(beta-trcp) complex, ubiquitin conjugated, and degraded. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
α-Catenin | up-regulates quantity
relocalization
|
CTNNB1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265818 |
|
|
Homo sapiens |
Colonic Cancer Cell |
| pmid |
sentence |
| 21598020 |
Overexpression of CTNNA3 in a CTNNA1 negative colon carcinoma cell line resulted in the reassembly of the adherens and tight junctions through the recruitment of CTNNA3 interacting partners such as E-cadherin, β-catenin, plakoglobin, and ZO-14 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SOX3 | down-regulates
binding
|
CTNNB1 |
0.489 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-72039 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10549281 |
Two additional sox proteins, xsox17alfa and xsox3, likewise bind to beta-catenin and inhibit its tcf-mediated signaling activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FOXM1 | up-regulates activity
binding
|
CTNNB1 |
0.528 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277211 |
|
|
Homo sapiens |
HEK-293T Cell |
| pmid |
sentence |
| 26912724 |
Nuclear FoxM1 then directly interacted with nuclear β‐catenin, which released β‐catenin from ICAT and enhanced recruitment of β‐catenin to the promoter of Wnt target gene, hence increasing the expression of Wnt target gene. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CTNNB1 | down-regulates activity
binding
|
SOX2 |
0.704 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-241994 |
|
|
Homo sapiens |
MCF-7 Cell |
| pmid |
sentence |
| 24291232 |
The interaction between Sox2 and _-catenin provides a novel mechanism underlying the functional dichotomy of BC cells, which carries potential therapeutic implications. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CDH20 | up-regulates activity
binding
|
CTNNB1 |
0.299 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265859 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21255999 |
At its C-terminus, cadherin interacts with β-catenin, which dynamically associates with α-catenin, a direct binding partner of filamentous actin |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
WNT1 | up-regulates
|
CTNNB1 |
0.746 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-85760 |
|
|
Rattus norvegicus |
|
| pmid |
sentence |
| 11149923 |
Wnt-1 signaling inhibited the cytochrome c release and the subsequent caspase-9 activation induced by chemotherapeutic drugs, including both vincristine and vinblastine. Furthermore, we found that wnt-1-mediated cell survival was dependent on the activation of beta-catenin/t cell factor (tcf) transcription |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| Pathways: | Colorectal Carcinoma, WNT Signaling, WNT Signaling and Myogenesis |
| + |
Cadherins | up-regulates activity
binding
|
CTNNB1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265812 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21255999 |
At its C-terminus, cadherin interacts with β-catenin, which dynamically associates with α-catenin, a direct binding partner of filamentous actin |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Neurotransmitters release |
| + |
PTPRZ1 | up-regulates activity
dephosphorylation
|
CTNNB1 |
0.38 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277044 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23100427 |
PTPRZ1 constitutively promotes the tyrosine dephosphorylation of \u03b2-catenin, and thus \u03b2-catenin participation in TCF-mediated transcription. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CTNNB1 | up-regulates quantity by expression
transcriptional regulation
|
CLDN2 |
0.312 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254114 |
|
|
Mus musculus |
C57MG Cell |
| pmid |
sentence |
| 14751232 |
Furthermore, claudin-2 promoter activity was found to be enhanced by the TCF-4/beta-catenin transcription complex. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
CTNNB1 | up-regulates
binding
|
EP300 |
0.699 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-76987 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10775268 |
Ctnnb1 forms a ternary complex with lef1 and ep300 that is disrupted by ctnnbip1 binding |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia, FLT3 in AML |
| + |
CHD8 | down-regulates
binding
|
CTNNB1 |
0.637 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-128976 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15367660 |
Duplin (axis duplication inhibitor) interacts with beta-catenin and prevents its binding to tcf, thereby inhibiting downstream wnt signaling |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RARA | down-regulates
|
CTNNB1 |
0.379 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-73274 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10607566 |
We shown that retinoic acid (ra) decreases the activity of the beta-catenin-lef/tcf signaling pathway |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia, Retinoic acid Signaling |
| + |
CTNNBIP1 | down-regulates activity
binding
|
CTNNB1 |
0.806 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-238012 |
|
|
in vitro |
|
| pmid |
sentence |
| 12408824 |
The crystal structure of the beta-catenin/ICAT complex reveals the inhibitory mechanism of ICAT. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
26S Proteasome | down-regulates quantity
destabilization
|
CTNNB1 |
0.404 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270340 |
|
|
Mus musculus |
C57MG Cell |
| pmid |
sentence |
| 9233789 |
Here we show that the ubiquitin-dependent proteolysis system is involved in the regulation of beta-catenin turnover. beta-catenin, but not E-cadherin, p120(cas) or alpha-catenin, becomes stabilized when proteasome-mediated proteolysis is inhibited and this leads to the accumulation of multi-ubiquitinated forms of beta-catenin. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270947 |
|
|
Mus musculus |
C57MG Cell |
| pmid |
sentence |
| 9233789 |
Here we show that the ubiquitin-dependent proteolysis system is involved in the regulation of beta-catenin turnover. beta-catenin, but not E-cadherin, p120(cas) or alpha-catenin, becomes stabilized when proteasome-mediated proteolysis is inhibited and this leads to the accumulation of multi-ubiquitinated forms of beta-catenin. |
|
| Publications: |
2 |
Organism: |
Mus Musculus |
| + |
AKT | up-regulates activity
|
CTNNB1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-244225 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16293724 |
We show that pge2 stimulates colon cancer cell growth through its heterotrimeric guanine nucleotide-binding protein (g protein) coupled receptor, ep2, by a signaling route that involves the activation of phosphoinositide 3-kinase and the protein kinase akt by free g protein bg subunits and the direct association of the g protein as subunit with the regulator of g protein signaling (rgs) domain of axin. This leads to the inactivation and release of glycogen synthase kinase 3b from its complex with axin, thereby relieving the inhibitory phosphorylation of b-catenin and activating its signaling pathway. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia, FLT3 in AML, FLT3-ITD in AML, FLT3-ITD signaling, Hepatocellular Tumor, Pancreatic ductal adenocarcinoma (PDA), Rhabdomyosarcoma, Thyroid cancer, WNT/FLT3 |
| + |
AXIN2 | down-regulates
|
CTNNB1 |
0.848 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-116480 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11940574 |
Although wnts act to stabilize _-catenin levels in the cytosol and nucleus, a multiprotein complex containing adenomatous polyposis coli, glycogen synthase kinase 3_, and axin1 or its homolog axin2/axil/conductin promotes _-catenin phosphorylation and subsequent proteasomal degradation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Breast |
| + |
CDH11 | up-regulates activity
binding
|
CTNNB1 |
0.646 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265851 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21255999 |
At its C-terminus, cadherin interacts with β-catenin, which dynamically associates with α-catenin, a direct binding partner of filamentous actin |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
BTRC | down-regulates
ubiquitination
|
CTNNB1 |
0.866 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-67374 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10228155 |
Here we show that fwd1 (the mouse homologue of slimb/betatrcp), an f-box/wd40-repeat protein, specifically formed a multi-molecular complex with beta-catenin, axin, gsk-3beta and apc. Mutations at the signal-induced phosphorylation site of beta-catenin inhibited its association with fwd1. Fwd1 facilitated ubiquitination and promoted degradation of beta-catenin, resulting in reduced cytoplasmic beta-catenin levels. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TRIM33 | down-regulates quantity by destabilization
binding, ubiquitination
|
CTNNB1 |
0.463 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260896 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25639486 |
Tumour suppressor TRIM33 targets nuclear β-catenin degradation |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278578 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25639486 |
TRIM33 ubiquitylates nuclear beta-catenin.|Tumour suppressor TRIM33 targets nuclear beta-catenin degradation. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
CDH24 | up-regulates activity
binding
|
CTNNB1 |
0.537 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265862 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21255999 |
At its C-terminus, cadherin interacts with β-catenin, which dynamically associates with α-catenin, a direct binding partner of filamentous actin |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CTNNB1 | down-regulates
|
CEBPA |
0.402 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-80589 |
|
|
Homo sapiens |
Myoblast |
| pmid |
sentence |
| 10937998 |
Wnt-10b, is a molecular switch that governs adipogenesis. Wnt signaling maintains preadipocytes in an undifferentiated state through inhibition of the adipogenic transcription factors ccaat/enhancer binding protein alpha (c/ebpalpha) and peroxisome proliferator- activated receptor gamma (ppargamma). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia, AML1-ETO in AML, FLT3 in AML, Onco-fusion proteins in AML, FLT3-ITD in AML |
| + |
CTNNB1 | up-regulates activity
binding
|
POU5F1 |
0.587 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-241981 |
|
|
Mus musculus |
Embryonic Stem Cell |
| pmid |
sentence |
| 21295277 |
We provide evidence suggesting that Beta-catenins interaction with the pluripotency regulator Oct-4 at least partially underlies its effects on sustaining pluripotency. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
WNT10B | up-regulates
|
CTNNB1 |
0.487 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-176190 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21872687 |
We show that knockdown of Beta-catenin completely prevents the inhibition of adipogenesis and stimulation of osteoblast differentiation by wnt6, wnt10a or wnt10b |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CDH7 | up-regulates activity
binding
|
CTNNB1 |
0.555 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265869 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21255999 |
At its C-terminus, cadherin interacts with β-catenin, which dynamically associates with α-catenin, a direct binding partner of filamentous actin |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TBL1X | up-regulates activity
binding
|
CTNNB1 |
0.646 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271954 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 20181957 |
TBL1 appears to serve two roles in regulating the activity of β-catenin. Besides the initially identified role of TBL1 in recruiting β-catenin to the SCF(TBL1) complex, it has also been shown to function as a transcriptional co-activator of β-catenin in recruiting it to the promoter site of Wnt target genes. Our results indicated that TBL1 can inhibit the polyubiquitination of β-catenin by Siah-1 in vitro (Fig. 3) and stabilize β-catenin in cells by protecting it from Siah-1-mediated ubiquitination and proteasomal degradation (Fig. 4). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SMAD7 | up-regulates
|
CTNNB1 |
0.696 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-133447 |
|
|
Homo sapiens |
Prostate Gland Cancer Cell |
| pmid |
sentence |
| 15684397 |
In the current study, our data indicate that both smad7 and p38 map kinase positively contributed to the accumulation of -catenin |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CTNNB1 | up-regulates
binding
|
TCF7 |
0.752 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-134282 |
|
|
Homo sapiens |
T-lymphocyte |
| pmid |
sentence |
| 15735151 |
Activated dvl binds and inhibits the phosphorylation of beta catenin by gsk3beta/alfa, blocking beta catenin degradation (fig 2?2),), so that beta catenin accumulates and translocates to the nucleus, where it interacts with the t cell specific factor (tcf)/lymphoid enhancer binding factor 1 (lef-1) transcription factor and induces the transcription of target genes such as c-jun, c-myc, and cyclin d1 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CTNNB1 | up-regulates activity
binding
|
SOX2 |
0.704 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-242087 |
|
|
Mus musculus |
MEF Cell |
| pmid |
sentence |
| 24482235 |
The interaction of Beta-catenin with Tcf is important for Beta-catenin s's function in iPSCs induction. In addition, Beta-catenin interacts with Oct4, Sox2, and Klf4, respectively. In the reprogramming process, Beta-catenin further enhances expression of pluripotency-related genes. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Tissue: |
HEK-293T Cell |
| + |
AR | down-regulates quantity by repression
transcriptional regulation
|
CTNNB1 |
0.728 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-116260 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 11916967 |
Transcription assays demonstrated that liganded ar repressed beta-catenin/t cell factor-responsive reporter gene activity |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FBXW11 | down-regulates
binding
|
CTNNB1 |
0.735 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-65429 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10074433 |
We conclude that beta-trcp is a component of an e3 ubiquitin ligase that is responsible for the targeted degradation of phosphorylated beta-catenin. we found that the binding of beta-trcp to beta-catenin was direct. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-60751 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9784611 |
we conclude that beta-trcp is a component of an e3 ubiquitin ligase that is responsible for the targeted degradation of phosphorylated beta-catenin.We Found that the binding of beta-trcp to beta-catenin was direct |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
Frizzled | up-regulates activity
|
CTNNB1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255652 |
|
|
|
|
| pmid |
sentence |
| 18697834 |
[…] we suggest that Wnt1, Wnt3a and Wnt5a result in the accumulation of Act-β-Cat |
|
| Publications: |
1 |
| Pathways: | Hepatocellular Tumor, Wnt in cancer, WNT Signaling, WNT/FLT3, WNT Signaling and Myogenesis |
| + |
MAML1 | up-regulates
binding
|
CTNNB1 |
0.28 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-157843 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17875709 |
Unexpectedly, however, emerging evidence implicate maml proteins as exciting key transcriptional co-activators in other signal transduction pathways including: muscle differentiation and myopathies (mef2c), tumor suppressor pathway (p53) and colon carcinoma survival (beta-catenin). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Muscle |
| + |
CHKA | down-regulates activity
phosphorylation
|
CTNNB1 |
0.291 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279161 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11818547 |
The data suggest that CKI phosphorylates and destabilizes the beta-catenin degradation complex, likely through the dissociation of PP2A, providing a mechanism by which CKI stabilizes beta-catenin and propagates the Wnt signal. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CHUK | up-regulates quantity
phosphorylation
|
CTNNB1 |
0.492 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280230 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22435559 |
Interestingly, while IKK2 negatively regulates beta-catenin stability similar to GSK3beta, IKK1 seems to increase beta-catenin protein level and downstream signal, such as cyclin D1 transcription.|These results suggested IKK1 may phosphorylate beta-catenin at different residues and protect it from ubiquitination mediated degradation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CTNNB1 | up-regulates quantity by expression
transcriptional regulation
|
CCND1 |
0.802 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-134216 |
|
|
Homo sapiens |
T-lymphocyte |
| pmid |
sentence |
| 15735151 |
Activated dvl binds and inhibits the phosphorylation of beta catenin by gsk3beta/alfa, blocking beta catenin degradation (fig 2?2),), so that beta catenin accumulates and translocates to the nucleus, where it interacts with the t cell specific factor (tcf)/lymphoid enhancer binding factor 1 (lef-1) transcription factor and induces the transcription of target genes such as c-jun, c-myc, and cyclin d1 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-98379 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12589056 |
The resulting accumulation of beta-catenin leads to its nuclear translocation and binding to tcf/lef transcription factors to induce target genes including cyclin d1. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia |
| + |
MEST | down-regulates
transcriptional regulation
|
CTNNB1 |
0.254 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-258982 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24827625 |
Our data demonstrate that Mest alleviated CCl4-induced collagen deposition in liver tissue and improved the condition of the liver in rats. Mest also significantly reduced the expression and distribution of β-catenin, α-SMA and Smad3 both in vivo and in vitro, in addition to the viability of HSCs in vitro. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CTNNB1 | up-regulates
binding
|
TRRAP |
0.568 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-144966 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16510874 |
The beta-cat c-terminal activation domain associates with trrap/tip60 and mixed-lineage-leukemia (mll1/mll2) set1-type chromatin-modifying complexes in vitro, and we show that beta-cat promotes h3k4 trimethylation at the c-myc gene in vivo. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DVL1 | up-regulates activity
binding
|
CTNNB1 |
0.805 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-134285 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15735151 |
Activated DVL binds and inhibits the phosphorylation of beta-catenin by GSK3B, blocking beta-catenin degradation so that beta catenin accumulates and translocates to the nucleus, where it interacts with the t cell specific factor (tcf)/lymphoid enhancer binding factor 1 (lef-1) transcription factor and induces the transcription of target genes such as c-jun, c-myc, and cyclin d1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia, FLT3-ITD in AML, Hepatocellular Tumor, Wnt in cancer, WNT Signaling, WNT/FLT3, WNT Signaling and Myogenesis |
| + |
APC | down-regulates quantity
binding
|
CTNNB1 |
0.917 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-177230 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22083140 |
Apc binds to both b-catenin and axin, and could shuttle b-catenin from the plasma membrane and nucleus to the cytoplasmic axin complex. APC cooperates with Axin to promote the phosphorylation of _-catenin by GSK3 [which requires priming phosphorylation by casein kinase 1, _-isoform (CK1_)]. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PTPN1 | up-regulates activity
dephosphorylation
|
CTNNB1 |
0.654 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277121 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12377785 |
PTP1B modulates the association of beta-catenin with N-cadherin through binding to an adjacent and partially overlapping target site.|The nonreceptor tyrosine phosphatase PTP1B associates with the cytoplasmic domain of N-cadherin and may regulate cadherin function through dephosphorylation of beta-catenin.|Thus, interaction of PTP1B with N-cadherin is essential for its association with beta-catenin, stable expression at the cell surface, and consequently, cadherin function. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IRF2BPL | down-regulates quantity by destabilization
ubiquitination
|
CTNNB1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267153 |
|
|
Homo sapiens |
Gastric Cancer Cell |
| pmid |
sentence |
| 29374064 |
FOXF2 directly bound the promoter of E3 ligase interferon regulatory factor 2-binding protein-like (IRF2BPL) and induced its transcriptional expression. IRF2BPL in turn interacted with β-catenin, increasing its ubiquitination and degradation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FANCL | up-regulates activity
ubiquitination
|
CTNNB1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278651 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22653977 |
Here we provide evidence that FANCL increases the activity and expression of beta-catenin, a key pluripotency factor in hematopoietic stem cells.|We show that FANCL ubiquitinates \u03b2-catenin with atypical ubiquitin chain extension known to have nonproteolytic functions. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GSK3B/Axin/APC | down-regulates
binding
|
CTNNB1 |
0.894 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-227881 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22083140 |
The role of apc is less clear, but it clearly binds to both b-catenin and axin, and could shuttle b-catenin from the plasma membrane and nucleus to the cytoplasmic axin complex. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-227862 |
|
|
Chlorocebus aethiops |
COS-7 Cell |
| pmid |
sentence |
| 9482734 |
Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta-catenin and promotes GSK-3beta-dependent phosphorylation of beta-catenin |
|
| Publications: |
2 |
Organism: |
Homo Sapiens, Chlorocebus Aethiops |
| Pathways: | Colorectal Carcinoma, Hepatocellular Tumor, Wnt in cancer, WNT Signaling, WNT Signaling and Myogenesis |
| + |
PTK7 | down-regulates
binding
|
CTNNB1 |
0.405 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-199536 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23151663 |
Ptk7 has been strongly implicated in pcp and, like many pcp activators, is a negative regulator of beta-catenin-dependent wnt. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
XAV939 | down-regulates
|
CTNNB1 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-188051 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19759537 |
Xav939 selectively inhibits beta-catenin-mediated transcription. Xav939 stimulates beta-catenin degradation by stabilizing axin, the concentration-limiting component of the destruction complex. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CTNNB1 | down-regulates
|
PPARG |
0.55 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-80592 |
|
|
Homo sapiens |
Myoblast |
| pmid |
sentence |
| 10937998 |
Wnt-10b, is a molecular switch that governs adipogenesis. Wnt signaling maintains preadipocytes in an undifferentiated state through inhibition of the adipogenic transcription factors ccaat/enhancer binding protein alpha (c/ebpalpha) and peroxisome proliferator- activated receptor gamma (ppargamma). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | PPARgamma in cancer, Thyroid cancer |
| + |
YAP1 | up-regulates
binding
|
CTNNB1 |
0.541 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-201939 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23607968 |
Additionally, the hippo and wnts also cooperate in the nucleus, where yap interacts with beta-catenin and induces the expression of canonical wnt target genes, such as sox2 and snai2 in mouse heart tissue. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Heart |
| + |
Frizzled | up-regulates
|
CTNNB1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255687 |
|
|
|
|
| pmid |
sentence |
| 23209147 |
The Wnt–FZD–LRP5/6 trimeric complex recruits Dishevelled (DVL) and Axin through the intracellular domains of FZD and LRP5/6, resulting in inhibition of β-catenin phosphorylation and thus ensuing β-catenin stabilization. |
|
| Publications: |
1 |
| Tissue: |
Skeletal Muscle |
| Pathways: | Hepatocellular Tumor, Wnt in cancer, WNT Signaling, WNT/FLT3, WNT Signaling and Myogenesis |
| + |
CTNNB1 | up-regulates quantity
transcriptional regulation
|
CCN4 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256270 |
|
|
Rattus norvegicus |
NRK-49F Cell |
| pmid |
sentence |
| 10716946 |
This study identifies WISP-1 as a beta-catenin-regulated gene that can contribute to tumorigenesis. The promoter of WISP-1 was cloned and shown to be activated by both Wnt-1 and beta-catenin expression. |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| + |
CUL1 | down-regulates quantity by destabilization
ubiquitination
|
CTNNB1 |
0.588 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-64499 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10023660 |
These results indicate that the cul1/skp1/beta-trcp complex forms a ubiquitin ligase that mediates the degradation of beta-catenin. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CTNNB1 | up-regulates
binding
|
NOTCH1 |
0.774 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-236858 |
|
|
Mus musculus |
C2C12 Cell |
| pmid |
sentence |
| 19000719 |
Beta-catenin can regulate the level and transcriptional activity of the notch1 and notch1 intracellular domain (nicd). The in vivo and in vitro results demonstrate that beta-catenin binds with notch1 and nicd, for which its armadillo repeat domain is essential. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Acute Myeloid Leukemia, FLT3-ITD in AML, FLT3-ITD signaling, Retinoic acid Signaling |
| + |
CTNNB1 | up-regulates
|
Cell_migration |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280436 |
|
|
Homo sapiens |
HuH-7 Cell |
| pmid |
sentence |
| 15480989 |
These observations suggest that the Wnt/β-catenin signal transduction pathway is involved much more commonly in the molecular pathogenesis of HCC than previously recognized because FZD7 overexpression occurred early in the disease process, stabilized wild-type β-catenin levels, and contributed to enhanced tumor cell migration. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | WNT Signaling |
| + |
CREB1 | up-regulates quantity by expression
transcriptional regulation
|
CTNNB1 |
0.463 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-76984 |
|
|
Xenopus laevis |
|
| pmid |
sentence |
| 10775268 |
Here we demonstrate that the closely related acetyltransferases p300 and cbp potentiate beta-catenin-mediated activation of the siamois promoter |
|
| Publications: |
1 |
Organism: |
Xenopus Laevis |
| Pathways: | FLT3-ITD signaling, WNT Signaling, WNT Signaling and Myogenesis |
4.0
CTNNB1
- 
- 