Summary

Name CEP85
Full Name Centrosomal protein of 85 kDa
Synonyms Cep85, Coiled-coil domain-containing protein 21 | CCDC21
Primary ID Q6P2H3
Links - -
Type protein
Relations 1
Function Acts as a regulator of centriole duplication through a direct interaction with STIL, a key factor involved in the early steps of centriole formation. The CEP85-STIL protein complex acts as a modulator of PLK4-driven cytoskeletal rearrangements and directional cell motility (PubMed:29712910, PubMed:32107292). Acts as a negative regulator of NEK2 to maintain the centrosome integrity in interphase. Suppresses centrosome disjunction by inhibiting NEK2 kinase activity (PubMed:26220856). {ECO:0000269|PubMed:26220856, ECO:0000269|PubMed:29712910, ECO:0000269|PubMed:32107292}.

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Relations

Regulator Mechanism target score ℹ
+ PLK1up-regulates activity img/direct-activation.png phosphorylation CEP85
Publications: 1 Organism: Homo Sapiens