Summary

Name PRPF8
Full Name Pre-mRNA-processing-splicing factor 8
Synonyms 220 kDa U5 snRNP-specific protein, PRP8 homolog, Splicing factor Prp8, p220 | PRPC8
Primary ID Q6P2Q9
Links - -
Type protein
Relations 1
Function Plays role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes, both of the predominant U2-type spliceosome and the minor U12-type spliceosome (PubMed:10411133, PubMed:11971955, PubMed:28502770, PubMed:28781166, PubMed:28076346, PubMed:29361316, PubMed:30315277, PubMed:29360106, PubMed:29301961, PubMed:30728453, PubMed:30705154). Functions as a scaffold that mediates the ordered assembly of spliceosomal proteins and snRNAs. Required for the assembly of the U4/U6-U5 tri-snRNP complex, a building block of the spliceosome. Functions as scaffold that positions spliceosomal U2, U5 and U6 snRNAs at splice sites on pre-mRNA substrates, so that splicing can occur. Interacts with both the 5' and the 3' splice site.

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Relations

Regulator Mechanism target score ℹ
+ PRPF8form complex img/form-complex.png binding U4/U6.U5 snRNP complex 0.772
Publications: 1 Organism: Homo Sapiens