3.0
Summary
| Name |  TRIM40
|
| Full Name | E3 ubiquitin ligase TRIM40 |
| Synonyms | Probable E3 NEDD8-protein ligase, RING finger protein 35 | RNF35 |
| Primary ID | Q6P9F5 |
| Links |  -  -  |
| Type | protein |
| Relations | 1 |
| Function | E3 ubiquitin-protein ligase that plays a role in the limitation of the innate immune response (PubMed:21474709, PubMed:29117565). Mediates inhibition of the RLR signaling pathway by ubiquitinating DDX58 and IFIH1 receptors, leading to their proteasomal degradation (PubMed:21474709). Promotes also the neddylation of IKBKG/NEMO, stabilizing NFKBIA, and thereby inhibiting of NF-kappa-B nuclear translocation and activation (PubMed:21474709). |
ubiquitination