| + |
GSK3B | up-regulates 
phosphorylation
|
BORA |
0.261 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-201515 |
Ser274 |
TSPSPISsPTFSPIE |
Homo sapiens |
|
| pmid |
sentence |
| 23442801 |
It suggests that gsk3_ activity is required for hbora-mediated mitotic entry through ser274 and ser278 phosphorylation |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-201519 |
Ser278 |
PISSPTFsPIEFQIG |
Homo sapiens |
|
| pmid |
sentence |
| 23442801 |
It suggests that gsk3_ activity is required for hbora-mediated mitotic entry through ser274 and ser278 phosphorylation |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
PLK1 | down-regulates 
phosphorylation
|
BORA |
0.78 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-178150 |
Ser497 |
SSNIQMDsGYNTQNC |
Homo sapiens |
|
| pmid |
sentence |
| 18378770 |
Following cdk1-dependent recruitment, plk1 triggers hbora destruction by phosphorylating a recognition site for scf(beta-trcp). |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-178803 |
Ser497 |
SSNIQMDsGYNTQNC |
Homo sapiens |
|
| pmid |
sentence |
| 18521620 |
Following cdk1-dependent recruitment, plk1 triggers hbora destruction by phosphorylating a recognition site for scf(beta-trcp). |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-178154 |
Thr501 |
QMDSGYNtQNCGSNI |
Homo sapiens |
|
| pmid |
sentence |
| 18378770 |
Following cdk1-dependent recruitment, plk1 triggers hbora destruction by phosphorylating a recognition site for scf(beta-trcp). |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-178807 |
Thr501 |
QMDSGYNtQNCGSNI |
Homo sapiens |
|
| pmid |
sentence |
| 18521620 |
Following cdk1-dependent recruitment, plk1 triggers hbora destruction by phosphorylating a recognition site for scf(beta-trcp). |
|
| Publications: |
4 |
Organism: |
Homo Sapiens |
| + |
CyclinA2/CDK1 | up-regulates activity
phosphorylation
|
BORA |
0.438 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267573 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 29870721 |
The active cyclin A/cdk1 complex phosphorylates Bora and promotes Plx1 activation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CyclinB/CDK1 | up-regulates activity
phosphorylation
|
BORA |
0.557 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-178799 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18521620 |
Our data additionally identify the cdk1 site s252 as critical for the recruitment of plk1 to hbora. collectively, our findings lead us to propose that hbora contributes to integrate the functions of three major mitotic kinases, cdk1, plk1, and aurora a. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
BORA | up-regulates
phosphorylation
|
PLK1 |
0.78 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-179425 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18615013 |
Bora/aurora-a-dependent phosphorylation is a prerequisite for plk1 to promote mitotic entry after a checkpoint-dependent arrest. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
BORA | up-regulates
binding
|
AURKA |
0.717 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-148661 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16890155 |
Both drosophila and human bora can bind to aurora-a and activate the kinase in vitro. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
BORA
- 
- 