Summary

Name KCNIP4
Full Name Kv channel-interacting protein 4
Synonyms KChIP4, A-type potassium channel modulatory protein 4, Calsenilin-like protein, Potassium channel-interacting protein 4 | CALP, KCHIP4
Primary ID Q6PIL6
Links - -
Type protein
Relations 1
Function Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Modulates KCND2 channel density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner (PubMed:11847232, PubMed:18957440, PubMed:23576435). Modulates KCND3/Kv4.3 currents (PubMed:23576435). Isoform 4 does not increase KCND2 expression at the cell membrane (PubMed:18957440). Isoform 4 retains KCND3 in the endoplasmic reticulum and negatively regulates its expression at the cell membrane.

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Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png relocalization KCND2 0.763
Publications: 1 Organism: Xenopus Laevis