Rai-like protein, RaLP, SHC-transforming protein D, hShcD, Src homology 2 domain-containing-transforming protein C4, SH2 domain protein C4 | SHCD
Primary ID
Q6S5L8
Links
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Type
protein
Relations
1
Function
Activates both Ras-dependent and Ras-independent migratory pathways in melanomas. Contributes to the early phases of agrin-induced tyrosine phosphorylation of CHRNB1. {ECO:0000269|PubMed:17409413}.
The luminescence obtained in the kinase assay with FLAG-ShcD as substrate was significantly different to that with FLAG peptide suggesting that ShcD is a direct substrate of ERK (Fig. 2C).Furthermore, Thr159 was mutated to either alanine (A) or glutamic acid (E) to study whether the threonine phosphorylation state influences the ShcD/ERK interaction. Introducing the T159E mutation obliterated the ShcD/ERK interaction.