Summary

Name SARM1
Full Name NAD
Synonyms Sterile alpha and Armadillo repeat protein, Sterile alpha motif domain-containing protein 2, MyD88-5, SAM domain-containing protein 2, Tir-1 homolog | KIAA0524, SAMD2, SARM
Primary ID Q6SZW1
Links - -
Type protein
Relations 2
Pathways Toll like receptors
Function NAD(+) hydrolase, which plays a key role in axonal degeneration following injury by regulating NAD(+) metabolism (PubMed:25908823, PubMed:27671644, PubMed:28334607). Acts as a negative regulator of MYD88- and TRIF-dependent toll-like receptor signaling pathway by promoting Wallerian degeneration, an injury-induced form of programmed subcellular death which involves degeneration of an axon distal to the injury site (PubMed:15123841, PubMed:16964262, PubMed:20306472, PubMed:25908823). Wallerian degeneration is triggered by NAD(+) depletion

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates activity img/direct_inhibition.png phosphorylation SARM1 0.437
Publications: 1
Pathways:Toll like receptors
+ down-regulates img/direct_inhibition.png binding TICAM1 0.552
Publications: 1 Organism: Mus Musculus
Pathways:Toll like receptors