4.0
Summary
| Name |  SARM1View Modifications |
| Full Name | NAD |
| Synonyms | Sterile alpha and Armadillo repeat protein, Sterile alpha motif domain-containing protein 2, MyD88-5, SAM domain-containing protein 2, Tir-1 homolog | KIAA0524, SAMD2, SARM |
| Primary ID | Q6SZW1 |
| Links |  -  -  |
| Type | protein |
| Relations | 2 |
| Pathways | Toll like receptors |
| Function | NAD(+) hydrolase, which plays a key role in axonal degeneration following injury by regulating NAD(+) metabolism (PubMed:25908823, PubMed:27671644, PubMed:28334607). Acts as a negative regulator of MYD88- and TRIF-dependent toll-like receptor signaling pathway by promoting Wallerian degeneration, an injury-induced form of programmed subcellular death which involves degeneration of an axon distal to the injury site (PubMed:15123841, PubMed:16964262, PubMed:20306472, PubMed:25908823). Wallerian degeneration is triggered by NAD(+) depletion |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | MAPK8 | down-regulates activity 
phosphorylation
|
SARM1 | 0.424 |
| Publications: | 1 | |||
| Pathways: | Toll like receptors | |||
| + | SARM1 | down-regulates
binding
|
TICAM1 | 0.532 |
| Publications: | 1 | Organism: | Mus Musculus | |
| Pathways: | Toll like receptors | |||