Summary

Name TICAM1
Full Name TIR domain-containing adapter molecule 1
Synonyms TICAM-1, Proline-rich, vinculin and TIR domain-containing protein B, Putative NF-kappa-B-activating protein 502H, Toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta, MyD88-3, TIR domain-containing adapter protein inducing IFN-beta | PRVTIRB, TRIF
Primary ID Q8IUC6
Links - -
Type protein
Relations 12
Pathways COVID-19 Causal Network, EBV infection, Innate Immune Response, Inflammosome Activation, Macrophage polarization, SARS-CoV INFLAMMATORY RESPONSE, SARS-CoV INNATE RESPONSE TO dsRNA, Toll like receptors
Function Involved in innate immunity against invading pathogens. Adapter used by TLR3, TLR4 (through TICAM2) and TLR5 to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis (PubMed:12471095, PubMed:12539043, PubMed:14739303, PubMed:28747347). Ligand binding to these receptors results in TRIF recruitment through its TIR domain (PubMed:12471095, PubMed:12539043, PubMed:14739303). Distinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively (PubMed:12471095, PubMed:12539043, PubMed:14739303). Phosphorylation by TBK1 on the pLxIS motif leads to recruitment and subsequent activation of the transcription factor IRF3 to induce expression of type I interferon and exert a potent immunity against invading pathogens (PubMed:25636800). Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines (By similarity).

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Relations

Regulator Mechanism target score ℹ
+ TLR4up-regulates activity img/direct-activation.png binding TICAM1 0.844
Publications: 1 Organism: Mus Musculus
Pathways:Macrophage polarization
+ DDX21up-regulates activity img/direct-activation.png binding TICAM1 0.27
Publications: 1 Organism: Mus Musculus
Pathways:COVID-19 Causal Network, Innate Immune Response, SARS-CoV INNATE RESPONSE TO dsRNA
+ TICAM1up-regulates activity img/direct-activation.png binding RIPK1 0.723
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, Innate Immune Response, Inflammosome Activation, Macrophage polarization, SARS-CoV INFLAMMATORY RESPONSE, SARS-CoV INNATE RESPONSE TO dsRNA
+ TLR2up-regulates activity img/direct-activation.png binding TICAM1 0.628
Publications: 1 Organism: Mus Musculus
Pathways:EBV infection
+ TRAF2up-regulates img/direct-activation.png polyubiquitination TICAM1 0.442
Publications: 1 Organism: Homo Sapiens
+ TLR9up-regulates activity img/direct-activation.png binding TICAM1 0.451
Publications: 1 Organism: Mus Musculus
Pathways:EBV infection
+ RNF216down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination TICAM1 0.362
Publications: 1 Organism: Homo Sapiens
+ SARM1down-regulates img/direct_inhibition.png binding TICAM1 0.546
Publications: 1 Organism: Mus Musculus
Pathways:Toll like receptors
+ TICAM1up-regulates activity img/direct-activation.png binding TBK1 0.814
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, EBV infection, Innate Immune Response, Inflammosome Activation, SARS-CoV INFLAMMATORY RESPONSE, SARS-CoV INNATE RESPONSE TO dsRNA, Toll like receptors
+ TICAM2up-regulates activity img/direct-activation.png binding TICAM1 0.568
Publications: 1 Organism: Homo Sapiens
Pathways:Macrophage polarization, Toll like receptors
+ TLRsup-regulates activity img/direct-activation.png binding TICAM1 0.2
Publications: 1 Organism: Mus Musculus
Pathways:COVID-19 Causal Network, Innate Immune Response, Inflammosome Activation, SARS-CoV INFLAMMATORY RESPONSE, Toll like receptors
+ TRAF6up-regulates img/direct-activation.png polyubiquitination TICAM1 0.823
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, EBV infection, Innate Immune Response, Inflammosome Activation, SARS-CoV INFLAMMATORY RESPONSE, Toll like receptors