| + |
AMPK | up-regulates activity 
phosphorylation
|
PAQR3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273737 |
Thr32 |
PRGIRLYtYEQIPGS |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 26834238 |
Firstly, PAQR3 functions as a scaffold protein that facilitates the formation of ATG14L- but not UVRAG-linked VPS34 complex, leading to elevated capacity of PI(3)P generation ahead of starvation signals. Secondly, AMPK phosphorylates PAQR3 at threonine 32 and switches on PI(3)P production to initiate autophagosome formation swiftly after glucose starvation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PAQR3 | up-regulates activity
binding
|
Vps34 Complex I |
0.252 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273738 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 26834238 |
Firstly, PAQR3 functions as a scaffold protein that facilitates the formation of ATG14L- but not UVRAG-linked VPS34 complex, leading to elevated capacity of PI(3)P generation ahead of starvation signals. Secondly, AMPK phosphorylates PAQR3 at threonine 32 and switches on PI(3)P production to initiate autophagosome formation swiftly after glucose starvation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
PAQR3
- 
- 