| + |
KLHL17 | up-regulates activity 
binding
|
Cullin 3-RBX1-Skp1 |
0.332 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271613 |
|
|
Chlorocebus aethiops |
COS-7 Cell |
| pmid |
sentence |
| 17062563 |
Here, we report that actinfilin is able to bind to GluR6, a kainate-type glutamate receptor subunit, and target GluR6 for degradation. Like many members of its protein family, actinfilin acts as a substrate adaptor, binding Cullin 3 (Cul3) and linking GluR6 to the E3 ubiquitin-ligase complex. Together our data demonstrate that actinfilin acts as a scaffold, linking GluR6 to the Cul3 ubiquitin ligase to provide a novel mechanism for kainate receptor degradation. |
|
| Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
| + |
KLHL17 | down-regulates quantity by destabilization 
binding
|
GRIK2 |
0.511 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271612 |
|
|
Chlorocebus aethiops |
COS-7 Cell |
| pmid |
sentence |
| 17062563 |
Here, we report that actinfilin is able to bind to GluR6, a kainate-type glutamate receptor subunit, and target GluR6 for degradation. Like many members of its protein family, actinfilin acts as a substrate adaptor, binding Cullin 3 (Cul3) and linking GluR6 to the E3 ubiquitin-ligase complex. Together our data demonstrate that actinfilin acts as a scaffold, linking GluR6 to the Cul3 ubiquitin ligase to provide a novel mechanism for kainate receptor degradation. |
|
| Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
3.0
KLHL17
- 
- 