| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268254 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16171773 |
A human mitochondrial isozyme of C1-tetrahydrofolate (THF) synthase was previously identified by its similarity to the human cytoplasmic C1-THF synthase. All C1-THF synthases characterized to date, from yeast to human, are trifunctional, containing the activities of 5,10-methylene-THF dehydrogenase, 5,10-methenyl-THF cyclohydrolase, and 10-formyl-THF synthetase. Here we report on the enzymatic characterization of the recombinant human mitochondrial isozyme. Enzyme assays of purified human mitochondrial C1-THF synthase protein revealed only the presence of 10-formyl-THF synthetase activity. |
|
3.0
MTHFD1L
- 
- 
chemical modification