Relation Results

Summary

Name LRSAM1
Full Name E3 ubiquitin-protein ligase LRSAM1
Synonyms Leucine-rich repeat and sterile alpha motif-containing protein 1, RING-type E3 ubiquitin transferase LRSAM1, Tsg101-associated ligase, hTAL | TAL
Primary ID Q6UWE0
Links - -
Type protein
Relations 2
Function E3 ubiquitin-protein ligase that mediates monoubiquitination of TSG101 at multiple sites, leading to inactivate the ability of TSG101 to sort endocyti ...
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Type: Score: Layout: SPV 
0.530.2LRSAM1TSG101Ub:E2

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Relations
Regulator
Mechanism
target
score ℹ
+ LRSAM1down-regulates quantity img/direct_inhibition.png monoubiquitination TSG101 0.53
Identifier Residue Sequence Organism Cell Line
SIGNOR-271509 Homo sapiens HEK-293 Cell
pmid sentence
Tal increases ubiquitylation of Tsg101 and affects its solubility in a RING- and PTAP-dependent manner.  Tal-mediated ubiquitylation of Tsg101 inactivates this sorting function and concomitantly translocates Tsg101 from relatively insoluble membrane subdomains. Presumably, the coordinated action of Tal and a deubiquitylation enzyme (DUB) enables recycling of Tsg101 and reloading of cargo.
Publications: 1 Organism: Homo Sapiens
+ Ub:E2up-regulates activity img/direct-activation.png ubiquitination LRSAM1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-271053 Homo sapiens
pmid sentence
The ubiquitination process is mediated sequentially by three classes of enzymes consisting of a Ub-activating enzyme E1, a Ub-conjugating enzyme E2, and a Ub ligase E3. Ub is first activated by E1 in an adenosine 5′-triphosphate (ATP)-dependent manner t
Publications: 1 Organism: Homo Sapiens
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