3.0
Summary
| Name |  LRSAM1
|
| Full Name | E3 ubiquitin-protein ligase LRSAM1 |
| Synonyms | Leucine-rich repeat and sterile alpha motif-containing protein 1, RING-type E3 ubiquitin transferase LRSAM1, Tsg101-associated ligase, hTAL | TAL |
| Primary ID | Q6UWE0 |
| Links |  -  -  |
| Type | protein |
| Relations | 2 |
| Function | E3 ubiquitin-protein ligase that mediates monoubiquitination of TSG101 at multiple sites, leading to inactivate the ability of TSG101 to sort endocytic (EGF receptors) and exocytic (HIV-1 viral proteins) cargos (PubMed:15256501). Bacterial recognition protein that defends the cytoplasm from invasive pathogens (PubMed:23245322). Localizes to several intracellular bacterial pathogens and generates the bacteria-associated ubiquitin signal leading to autophagy-mediated intracellular bacteria degradation (xenophagy) (PubMed:23245322, PubMed:25484098). |
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monoubiquitination
ubiquitination