3.0
Summary
| Name |  ABRAXAS1View Modifications |
| Full Name | BRCA1-A complex subunit Abraxas 1 |
| Synonyms | Coiled-coil domain-containing protein 98, Protein FAM175A | ABRA1, CCDC98 |
| Primary ID | Q6UWZ7 |
| Links |  -  -  |
| Type | protein |
| Relations | 4 |
| Function | Involved in DNA damage response and double-strand break (DSB) repair. Component of the BRCA1-A complex, acting as a central scaffold protein that assembles the various components of the complex and mediates the recruitment of BRCA1. The BRCA1-A complex specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesion sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at DSBs. This complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | ATM | up-regulates activity 
phosphorylation
|
ABRAXAS1 | 0.2 |
| Publications: | 2 | Organism: | Homo Sapiens | |
| + | ABRAXAS1 | form complex 
binding
|
BRCA1-A complex | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | ABRAXAS1 | up-regulates
binding
|
BRCA1 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |