Summary

Name GIGYF2
Full Name GRB10-interacting GYF protein 2
Synonyms GRB10-interacting GYF protein 2, Trinucleotide repeat-containing gene 15 protein | KIAA0642, PERQ2, TNRC15
Primary ID Q6Y7W6
Links - -
Type protein
Relations 4
Function Key component of the 4EHP-GYF2 complex, a multiprotein complex that acts as a repressor of translation initiation (PubMed:22751931, PubMed:31439631). In the 4EHP-GYF2 complex, acts as a factor that bridges EIF4E2 to ZFP36/TTP, linking translation repression with mRNA decay (PubMed:31439631). Also recruits and bridges the association of the 4EHP complex with the decapping effector protein DDX6, which is required for the ZFP36/TTP-mediated down-regulation of AU-rich mRNA (PubMed:31439631). May act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling, including IGF1 and insulin receptors (PubMed:12771153).

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Regulator Mechanism target score ℹ
+ MAPK1