3.0
Summary
| Name |  GIGYF2View Modifications |
| Full Name | GRB10-interacting GYF protein 2 |
| Synonyms | GRB10-interacting GYF protein 2, Trinucleotide repeat-containing gene 15 protein | KIAA0642, PERQ2, TNRC15 |
| Primary ID | Q6Y7W6 |
| Links |  -  -  |
| Type | protein |
| Relations | 4 |
| Function | Key component of the 4EHP-GYF2 complex, a multiprotein complex that acts as a repressor of translation initiation (PubMed:22751931, PubMed:31439631). In the 4EHP-GYF2 complex, acts as a factor that bridges EIF4E2 to ZFP36/TTP, linking translation repression with mRNA decay (PubMed:31439631). Also recruits and bridges the association of the 4EHP complex with the decapping effector protein DDX6, which is required for the ZFP36/TTP-mediated down-regulation of AU-rich mRNA (PubMed:31439631). May act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling, including IGF1 and insulin receptors (PubMed:12771153). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | MAPK1 |
phosphorylation
|
GIGYF2 | 0.2 |
| Publications: | 1 | Organism: | Mus Musculus | |
| + | CNOT9 | up-regulates activity 
binding
|
GIGYF2 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | GIGYF2 | form complex 
binding
|
EIF4E2/GIGYF2 complex | 0.717 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | GIGYF2 | up-regulates activity
binding
|
GRB10 | 0.622 |
| Publications: | 1 | Organism: | Mus Musculus | |