3.0
Summary
| Name |  HECW1
|
| Full Name | E3 ubiquitin-protein ligase HECW1 |
| Synonyms | HECT, C2 and WW domain-containing protein 1, HECT-type E3 ubiquitin transferase HECW1, NEDD4-like E3 ubiquitin-protein ligase 1, hNEDL1 | KIAA0322, NEDL1 |
| Primary ID | Q76N89 |
| Links |  -  -  |
| Type | protein |
| Relations | 2 |
| Function | E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent degradation of DVL1. Also targets the mutant SOD1 protein involved in familial amyotrophic lateral sclerosis (FALS). Forms cytotoxic aggregates with DVL1, SSR3 and mutant SOD1 that lead to motor neuron death in FALS. |
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ubiquitination
ubiquitination