Relation Results

Summary

Name HECW1
Full Name E3 ubiquitin-protein ligase HECW1
Synonyms HECT, C2 and WW domain-containing protein 1, HECT-type E3 ubiquitin transferase HECW1, NEDD4-like E3 ubiquitin-protein ligase 1, hNEDL1 | KIAA0322, NEDL1
Primary ID Q76N89
Links - -
Type protein
Relations 2
Function E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent degradation of DVL1. Also targets the mutant SOD1 protein involved in familial ...
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Type: Score: Layout: SPV 
0.20.639Ub:E2HECW1DVL1

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Relations
Regulator
Mechanism
target
score ℹ
+ Ub:E2up-regulates activity img/direct-activation.png ubiquitination HECW1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-271302 Homo sapiens
pmid sentence
The ubiquitination process is mediated sequentially by three classes of enzymes consisting of a Ub-activating enzyme E1, a Ub-conjugating enzyme E2, and a Ub ligase E3. Ub is first activated by E1 in an adenosine 5′-triphosphate (ATP)-dependent manner t
Publications: 1 Organism: Homo Sapiens
+ HECW1down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination DVL1 0.639
Identifier Residue Sequence Organism Cell Line
SIGNOR-271499 Mus musculus Neuro-2a Cell
pmid sentence
We have also found that NEDL1 targets Dishevelled-1 (Dvl1) for ubiquitination-mediated degradation and that mutant (but not wild-type) SOD1 affects the function of Dvl1. 
Publications: 1 Organism: Mus Musculus
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