| + |
CSNK1E | up-regulates activity 
phosphorylation
|
DVL1 |
0.624 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-217845 |
Ser139 |
DNETGTEsMVSHRRE |
Homo sapiens |
|
| pmid |
sentence |
| 16965538 |
Phenotypic analysis of mutant mDvl-1 indicates that phosphorylation of these sites stimulates the Dvl-activated beta-catenin-dependent Wnt signaling pathway in both cell culture and in Xenopus development. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-217849 |
Ser142 |
TGTESMVsHRRERAR |
Homo sapiens |
|
| pmid |
sentence |
| 16965538 |
Phenotypic analysis of mutant mDvl-1 indicates that phosphorylation of these sites stimulates the Dvl-activated beta-catenin-dependent Wnt signaling pathway in both cell culture and in Xenopus development. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
DVL1 | down-regulates activity 
binding
|
GSK3B |
0.61 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-167957 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20837657 |
In canonical wnt signaling, dsh phosphorylation inhibits the apcaxingsk3 complex, leading to beta-catenin stabilization. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia, WNT/FLT3 |
| + |
DVL1 | up-regulates activity 
|
RAC1 |
0.569 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-199384 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23151663 |
In pcp , dvl binds to proteins such as pkc, atypical pkc (apkc), dvl associated activator of morphogenesis 1 (daam1), dvl-associating protein with a high frequency of leu residues (daple) and partitioning defective 6 (par6), which are important for the regulation of small gtpases such as rho and rac and, consequently, the cytoskeleton and cell polarity58. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia, FLT3-ITD in AML, WNT Signaling, WNT/FLT3, WNT Signaling and Myogenesis |
| + |
DVL1 | up-regulates
binding
|
JUN |
0.47 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-178038 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 18347071 |
In this study, we discovered two novel interactions between dvl and c-jun and between dvl and beta-catenin in the nucleus that mediate the formation of a dvlc-junbeta-catenintcf functional complex. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia, WNT Signaling, WNT/FLT3, WNT Signaling and Myogenesis |
| + |
SDC4 | up-regulates
binding
|
DVL1 |
0.361 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-199632 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23151663 |
Like other wnt co-receptors, syndecan 4 directly interacts with dvl during pcp 1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DVL1 | down-regulates activity
binding
|
GSK3B/Axin/APC |
0.704 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-227917 |
|
|
Chlorocebus aethiops |
COS Cell |
| pmid |
sentence |
| 10196136 |
We have recently found that Dvl-1 directly binds to Axin and that the binding of Dvl-1 to Axin does not affect the interaction of GSK-3beta with Axin. It is possible that the binding of Dvl to Axin induces the structural change of the Axin complex; therefore GSK-3beta does not effectively phosphorylate Axin. This is the first demostration showing that Dvl inhibits the function of GSK-3beta directly. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-227911 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20837657 |
In canonical wnt signaling, dsh phosphorylation inhibits the apcaxingsk3 complex, leading to beta-catenin stabilization. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-227914 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20837657 |
In canonical wnt signaling, dsh phosphorylation inhibits the apcaxingsk3 complex, leading to beta-catenin stabilization. |
|
| Publications: |
3 |
Organism: |
Chlorocebus Aethiops, Homo Sapiens |
| Pathways: | Hepatocellular Tumor, Wnt in cancer, WNT Signaling, WNT Signaling and Myogenesis |
| + |
INVS | down-regulates
ubiquitination
|
DVL1 |
0.634 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-135766 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15852005 |
Inversin inhibits the canonical wnt pathway by targeting cytoplasmic dishevelled (dsh or dvl1) for degradation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FZD5 | up-regulates activity
binding
|
DVL1 |
0.649 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-258957 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23151663 |
Upon ligand binding, DVL proteins are recruited to Frizzled receptors at the plasma membrane and co-recruit cytoplasmic transducers, such as Axin, CK1 and GSK3 binding protein (GBP), presumably along with their partners, to promote ?-catenin-dependent signalling. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Frizzled | up-regulates
binding
|
DVL1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255891 |
|
|
|
|
| pmid |
sentence |
| 19279717 |
Wnt signaling is transduced through Fz independent of LRP5/6 leading to the activation of Dsh. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255892 |
|
|
|
|
| pmid |
sentence |
| 19279717 |
After binding of Wnt to the receptor complex, the signal is transduced to cytoplasmic phosphoprotein Dishevelled (Dsh/Dvl), and studies have uncovered that Dsh can directly interact with Fz |
|
| Publications: |
2 |
| Pathways: | Hepatocellular Tumor, Wnt in cancer, WNT Signaling, WNT/FLT3, WNT Signaling and Myogenesis |
| + |
DVL1 | down-regulates activity
binding
|
AXIN1 |
0.815 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-219356 |
|
|
Chlorocebus aethiops |
|
| pmid |
sentence |
| 10196136 |
We have recently found that Dvl-1 directly binds to Axin and that the binding of Dvl-1 to Axin does not affect the interaction of GSK-3beta with Axin. It is possible that the binding of Dvl to Axin induces the structural change of the Axin complex; therefore GSK-3beta does not effectively phosphorylate Axin. This is the first demostration showing that Dvl inhibits the function of GSK-3beta directly. |
|
| Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
| + |
DVL1 | up-regulates activity
binding
|
LRP6 |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-156072 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17569865 |
The scaffold protein dishevelled (dvl) is required for lrp6 phosphorylation and aggregation. We propose that wnts induce coclustering of receptors and dvl in lrp6-signalosomes, which in turn triggers lrp6 phosphorylation to promote axin recruitment and beta-catenin stabilization. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | WNT Signaling, WNT/FLT3, WNT Signaling and Myogenesis |
| + |
DVL1 | up-regulates activity
binding
|
RAC1 |
0.569 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-185274 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19365405 |
B-catenin-independent wnt signaling can activate rho family gtpases through at least two mechanisms: (1) direct activation of rac1 by dvl;and (2) activation of rhoa via dvl-associated activator of morphogenesis-1 (daam1), possibly through the weak-similarity guaninenucleotide exchange factor (wgef)1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia, FLT3-ITD in AML, WNT Signaling, WNT/FLT3, WNT Signaling and Myogenesis |
| + |
FZD1 | up-regulates activity
binding
|
DVL1 |
0.679 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253512 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22944199 |
When canonical wnts bind to their respective fzd receptors, heterotrimeric g-proteins and dsh get activated and lead to the recruitment of axin to the fzd co-receptor lrp. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ANAPC2 | down-regulates
binding
|
DVL1 |
0.24 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-188393 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19805045 |
We now report that the anaphase-promoting complex (apc/c) recognizes a d-box motif of dvl and ubiquitylates dvl on a highly conserved lysine residue.We now report that expression of the apc/c subunit anapc2 activates the apc/c-dependent degradation of dvl by disrupting canonical wnt signaling. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Cullin 3-RBX1-Skp1 | down-regulates quantity by destabilization
polyubiquitination
|
DVL1 |
0.41 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271562 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 16547521 |
KLHL12 recruits Dsh to Cullin-3 for protein degradation. In vitro ubiquitination of Dsh3 by KLHL12–Cullin-3–Roc1. The E3 ligase complex was obtained by transfection of HEK293T cells . We show that the BTB-containing protein KLHL12 negatively regulates Dsh function by recruiting a pool of Dsh to the Cullin-3 ligase scaffold, thereby promoting its ubiquitination and degradation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
LRP6 | up-regulates activity
binding
|
DVL1 |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-262526 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23209147 |
The Wnt–FZD–LRP5/6 trimeric complex recruits Dishevelled (DVL) and Axin through the intracellular domains of FZD and LRP5/6, resulting in inhibition of β-catenin phosphorylation and thus ensuing β-catenin stabilization. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | WNT Signaling, WNT/FLT3, WNT Signaling and Myogenesis |
| + |
WNT5A | up-regulates activity
|
DVL1 |
0.709 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-169666 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21078818 |
Common mechanism that involves their wnt-dependent coupling to the frizzled (fzd) coreceptor and recruitment of shared components, including dishevelled (dvl), axin, and glycogen synthase kinase 3 (gsk3). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | WNT Signaling, WNT Signaling and Myogenesis |
| + |
DVL1 | up-regulates activity
binding
|
DAAM1 |
0.727 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-185271 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19365405 |
B-catenin-independent wnt signaling can activate rho family gtpases through at least two mechanisms: (1) direct activation of rac1 by dvl;and (2) activation of rhoa via dvl-associated activator of morphogenesis-1 (daam1), possibly through the weak-similarity guaninenucleotide exchange factor (wgef)1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | WNT Signaling, WNT/FLT3, WNT Signaling and Myogenesis |
| + |
DVL1 | up-regulates activity
binding
|
RHOA |
0.613 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-258971 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 27571105 |
Although there are other activators of PCP, Wnt5a can activate the PCP pathway by forming a complex with Fzd and Ror2 receptors, activating DVL, which in turn activates Rho-family small GTPases, including RhoA and Rac, and their downstream effectors, Rho-associated protein kinase (ROCK), the actin-binding protein, Filamin A and c-Jun N-terminal protein kinase (JNK) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | WNT Signaling, WNT/FLT3, WNT Signaling and Myogenesis |
| + |
DVL1 | up-regulates activity
|
PLCB1 |
0.278 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-258978 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19279717 |
Dsh through PLC activates IP3, which leads to release of intracellular Ca2+, which in turn activates CamK11 and calcineurin |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
LRP5 | up-regulates activity
binding
|
DVL1 |
0.679 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-262525 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23209147 |
The Wnt–FZD–LRP5/6 trimeric complex recruits Dishevelled (DVL) and Axin through the intracellular domains of FZD and LRP5/6, resulting in inhibition of β-catenin phosphorylation and thus ensuing β-catenin stabilization. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | WNT Signaling, WNT Signaling and Myogenesis |
| + |
WWTR1 | down-regulates
binding
|
DVL1 |
0.363 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-195212 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22153608 |
Taz binds to dvl proteins, thereby inhibiting dvl phosphorylation by casein kinase 1-delta and -epsilon kinases (ck1d/e), thus promoting beta-catenin degradation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DVL1 | up-regulates
|
RND1 |
0.276 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-199387 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23151663 |
In pcp , dvl binds to proteins such as pkc, atypical pkc (apkc), dvl?associated Activator of morphogenesis 1 (daam1), dvl-associating protein with a high frequency of leu residues (daple) and partitioning defective 6 (par6), which are important for the regulation of small gtpases such as rho and rac and, consequently, the cytoskeleton and cell polarity58. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HECW1 | down-regulates quantity by destabilization
ubiquitination
|
DVL1 |
0.629 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271499 |
|
|
Mus musculus |
Neuro-2a Cell |
| pmid |
sentence |
| 14684739 |
We have also found that NEDL1 targets Dishevelled-1 (Dvl1) for ubiquitination-mediated degradation and that mutant (but not wild-type) SOD1 affects the function of Dvl1. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
SMAD1 | up-regulates
binding
|
DVL1 |
0.351 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-146131 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16621789 |
These results identify a potential mechanism whereby bmp-2 antagonizes wnt signaling in osteoblast progenitors by promoting an interaction between smad1 and dvl-1 that restricts beta-catenin activation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DVL1 | down-regulates activity
binding
|
APC |
0.686 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-167951 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10330181 |
Dvl-1 inhibits Axin-promoted GSK-3_-dependent phosphorylation of _-catenin and APC, leading to beta-catenin stabilization. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FZD2 | up-regulates activity
binding
|
DVL1 |
0.657 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-258956 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23151663 |
Upon ligand binding, DVL proteins are recruited to Frizzled receptors at the plasma membrane and co-recruit cytoplasmic transducers, such as Axin, CK1 and GSK3 binding protein (GBP), presumably along with their partners, to promote ?-catenin-dependent signalling. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
WNT3A | up-regulates activity
|
DVL1 |
0.68 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-180803 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18772438 |
Wnt3a stimulates the formation of phosphatidylinositol 4,5-bisphosphates [ptdins (4,5)p2] through frizzled and dishevelled, the latter of which directly interacted with and activated pip5ki. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | WNT Signaling, WNT Signaling and Myogenesis |
| + |
KLHL12 | down-regulates quantity by destabilization
binding
|
DVL1 |
0.608 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271558 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 16547521 |
KLHL12 recruits Dsh to Cullin-3 for protein degradation. In vitro ubiquitination of Dsh3 by KLHL12–Cullin-3–Roc1. The E3 ligase complex was obtained by transfection of HEK293T cells . We show that the BTB-containing protein KLHL12 negatively regulates Dsh function by recruiting a pool of Dsh to the Cullin-3 ligase scaffold, thereby promoting its ubiquitination and degradation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DVL1 | up-regulates activity
binding
|
CTNNB1 |
0.801 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-134285 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15735151 |
Activated DVL binds and inhibits the phosphorylation of beta-catenin by GSK3B, blocking beta-catenin degradation so that beta catenin accumulates and translocates to the nucleus, where it interacts with the t cell specific factor (tcf)/lymphoid enhancer binding factor 1 (lef-1) transcription factor and induces the transcription of target genes such as c-jun, c-myc, and cyclin d1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia, FLT3-ITD in AML, Hepatocellular Tumor, Wnt in cancer, WNT Signaling, WNT/FLT3, WNT Signaling and Myogenesis |
| + |
RYK | up-regulates
binding
|
DVL1 |
0.495 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-129568 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15454084 |
Ryk also binds to dishevelled, through which it activates the canonical wnt, providing a link between wnt and dishevelled. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FZD4 | up-regulates activity
binding
|
DVL1 |
0.595 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-258955 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 27096005 |
Through study of FZD4 and its associated ligand Norrin, we report that a minimum of three residues distal to the KTXXXW motif in the C-terminal tail of Frizzled-4 are essential for DVL recruitment and robust Lef/Tcf-dependent transcriptional activation in response to Norrin. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia, FLT3-ITD in AML |
| + |
FZD6 | up-regulates activity
binding
|
DVL1 |
0.669 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-198828 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22944199 |
When canonical wnts bind to their respective fzd receptors, heterotrimeric g-proteins and dsh get activated and lead to the recruitment of axin to the fzd co-receptor lrp. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FZD3 | up-regulates activity
binding
|
DVL1 |
0.649 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-134288 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22944199 |
When canonical wnts bind to their respective fzd receptors, heterotrimeric g-proteins and dsh get activated and lead to the recruitment of axin to the fzd co-receptor lrp. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FZD7 | up-regulates
binding
|
DVL1 |
0.651 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255893 |
|
|
|
|
| pmid |
sentence |
| 22179044 |
In non-canonical Wnt signalling, Wnt proteins bind Fzd and glypican-4, to activate Dsh at the cell membrane, leading to activation of Rho and JNK |
|
| Publications: |
1 |
| + |
YAP1 | down-regulates
binding
|
DVL1 |
0.339 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-199806 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23178811 |
Yap restricts elevated wnt independently of the axinapcgsk-3beta complex partly by limiting the activity of dishevelled (dvl). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Frizzled | up-regulates activity
binding
|
DVL1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253124 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22944199 |
When canonical wnts bind to their respective fzd receptors, heterotrimeric g-proteins and dsh get activated and lead to the recruitment of axin to the fzd co-receptor lrp. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Hepatocellular Tumor, Wnt in cancer, WNT Signaling, WNT/FLT3, WNT Signaling and Myogenesis |
3.0
DVL1
- 
- 