3.0
Summary
| Name |  LPCAT2View Modifications |
| Full Name | Lysophosphatidylcholine acyltransferase 2 |
| Synonyms | LPC acyltransferase 2, LPCAT-2, LysoPC acyltransferase 2, 1-acylglycerol-3-phosphate O-acyltransferase 11, 1-AGP acyltransferase 11, 1-AGPAT 11, 2.3.1.51, 1-acylglycerophosphocholine O-acyltransferase, 1-alkylglycerophosphocholine O-acetyltransferase, 2.3.1.67, Acetyl-CoA:lyso-platelet-activating factor acetyltransferase, Acetyl-CoA:lyso-PAF acetyltransferase, Lyso-PAF acetyltransferase, LysoPAFAT, Acyltransferase-like 1, Lysophosphatidic acid acyltransferase alpha, LPAAT-alpha | AGPAT11, AYTL1 |
| Primary ID | Q7L5N7 |
| Links |  -  -  |
| Type | protein |
| Relations | 5 |
| Function | Exhibits both acyltransferase and acetyltransferase activities (PubMed:17182612, PubMed:20363836, PubMed:21498505). Catalyzes the conversion of lysophosphatidylcholine (1-acyl-sn-glycero-3-phosphocholine or LPC) into phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine or PC) (PubMed:21498505). Catalyzes the conversion 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (PubMed:20363836). Involved in platelet-activating factor (PAF) biosynthesis by catalyzing the conversion of the PAF precursor, 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF) into 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (PAF) (PubMed:17182612). Also converts lyso-PAF to 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine (PC), a major component of cell membranes and a PAF precursor (By similarity). Under resting conditions, acyltransferase activity is preferred (By similarity). Upon acute inflammatory stimulus, acetyltransferase activity is enhanced and PAF synthesis increases (By similarity). Involved in the regulation of lipid droplet number and size (PubMed:25491198). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | MAPKAPK2 | up-regulates activity 
phosphorylation
|
LPCAT2 | 0.2 |
| Publications: | 1 | Organism: | Mus Musculus | |
| + | LPCAT2 | up-regulates quantity
chemical modification
|
1,2-diacyl-sn-glycero-3-phosphocholine | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | LPCAT2 | down-regulates quantity 
chemical modification
|
acyl-CoA(4-) | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | LPCAT2 | up-regulates quantity
chemical modification
|
coenzyme A(4-) | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | LPCAT2 | down-regulates quantity
chemical modification
|
1-O-acyl-sn-glycero-3-phosphocholine | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |