Summary

Name MAPKAPK2
Full Name MAP kinase-activated protein kinase 2
Synonyms MAPK-activated protein kinase 2, MAPKAP kinase 2, MAPKAP-K2, MAPKAPK-2, MK-2, MK2
Primary ID P49137
Links - -
Type protein
Relations 53
Pathways P38 Signaling
Function Stress-activated serine/threonine-protein kinase involved in cytokine production, endocytosis, reorganization of the cytoskeleton, cell migration, cell cycle control, chromatin remodeling, DNA damage response and transcriptional regulation. Following stress, it is phosphorylated and activated by MAP kinase p38-alpha/MAPK14, leading to phosphorylation of substrates. Phosphorylates serine in the peptide sequence, Hyd-X-R-X(2)-S, where Hyd is a large hydrophobic residue. Phosphorylates ALOX5, CDC25B, CDC25C, CEP131, ELAVL1, HNRNPA0, HSP27/HSPB1, KRT18, KRT20, LIMK1, LSP1, PABPC1, PARN, PDE4A, RCSD1, RPS6KA3, TAB3 and TTP/ZFP36. Phosphorylates HSF1; leading to the interaction with HSP90 proteins and inhibiting HSF1 homotrimerization, DNA-binding and transactivation activities (PubMed:16278218). Mediates phosphorylation of HSP27/HSPB1 in response to stress, leading to the dissociation of HSP27/HSPB1 from large small heat-shock protein (sHsps) oligomers and impairment of their chaperone activities and ability to protect against oxidative stress effectively. Involved in inflammatory response by regulating tumor necrosis factor (TNF) and IL6 production post-transcriptionally

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Modifications Tables

Relations

Regulator Mechanism target score
+ img/unknown.png phosphorylation SRF 0.32
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation RTN4 0.35
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation ZFP36 0.51
Publications: 5 Organism: In Vitro
+ img/unknown.png phosphorylation TSC2 0.20
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation CREB1 0.15
Publications: 2 Organism: Homo Sapiens
Pathways:P38 Signaling
+ up-regulates img/direct-activation.png phosphorylation CREB1
Publications: 1 Organism: Homo Sapiens
Pathways:P38 Signaling
+ down-regulates img/direct_inhibition.png phosphorylation HSPB1 0.69
Publications: 5 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation MDM2 0.06
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation TH 0.13
Publications: 2 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png phosphorylation ETV1 0.43
Publications: 2 Organism: Neovison Vison
+ up-regulates img/direct-activation.png phosphorylation BAG2 0.55
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation ZFP36L1 0.56
Publications: 3 Organism: Homo Sapiens
+ img/unknown.png phosphorylation LSP1 0.52
Publications: 2 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation MAPKAPK2 0.16
Publications: 3 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation MAPKAPK2 0.58
Publications: 6 Organism: Homo Sapiens, In Vitro
Pathways:P38 Signaling
+ up-regulates activity img/direct-activation.png phosphorylation ALOX5 0.14
Publications: 1 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation LIMK1 0.37
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PLK1
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation EEF2K 0.59
Publications: 1 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation AGO2 0.42
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PIAS1 0.37
Publications: 1 Organism: Homo Sapiens
Tissue: Skin
+ down-regulates img/direct_inhibition.png phosphorylation PARN 0.47
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation YWHAZ 0.47
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation ARPC5
Publications: 1 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation AATF 0.48
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation TCF3 0.38
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CDC25A 0.32
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation ETV1 0.43
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation ELAVL1 0.47
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation MAPKAPK2 0.22
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation SRF 0.32
Publications: 1 Organism: Homo Sapiens