3.0
Summary
| Name |  TICRRView Modifications |
| Full Name | Treslin |
| Synonyms | TopBP1-interacting checkpoint and replication regulator, TopBP1-interacting, replication-stimulating protein | C15orf42 |
| Primary ID | Q7Z2Z1 |
| Links |  -  -  |
| Type | protein |
| Relations | 1 |
| Function | Regulator of DNA replication and S/M and G2/M checkpoints. Regulates the triggering of DNA replication initiation via its interaction with TOPBP1 by participating in CDK2-mediated loading of CDC45L onto replication origins. Required for the transition from pre-replication complex (pre-RC) to pre-initiation complex (pre-IC). Required to prevent mitotic entry after treatment with ionizing radiation. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | CyclinE/CDK2 | up-regulates activity 
phosphorylation
|
TICRR | 0.343 |
| Publications: | 1 | Organism: | In Vitro | |