Relation Results

Name	RNF144B
Full Name	E3 ubiquitin-protein ligase RNF144B
Synonyms	IBR domain-containing protein 2, RING finger protein 144B, p53-inducible RING finger protein \| IBRDC2, P53RFP
Primary ID	Q7Z419
Links	- -
Type	protein
Relations	3
Function	E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates such as LCMT2, thereby promoting their degradation. Induces apoptosis via a p53/TP53-dependent but caspase-independent mechanism. However, its overexpression also produces a decrease of the ubiquitin-dependent stability of BAX, a pro-apoptotic protein, ultimately leading to protection of cell death; But, it is not an anti-apoptotic protein per se.