Summary

Name NPM1
Full Name Nucleophosmin
Synonyms NPM, Nucleolar phosphoprotein B23, Nucleolar protein NO38, Numatrin | NPM
Primary ID P06748
Links - -
Type protein
Relations 28
Pathways Acute Myeloid Leukemia, DNMT3A in AML, Onco-fusion proteins in AML, NPM1 in AML, AML_TRIPLETS, Triple mutant AML, NPM1_new
Function Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF. Binds ribosome presumably to drive ribosome nuclear export. Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. Acts as a chaperonin for the core histones H3, H2B and H4. Stimulates APEX1 endonuclease activity on apurinic/apyrimidinic (AP) double-stranded DNA but inhibits APEX1 endonuclease activity on AP single-stranded RNA. May exert a control of APEX1 endonuclease activity within nucleoli devoted to repair AP on rDNA and the removal of oxidized rRNA molecules. In concert with BRCA2, regulates centrosome duplication. Regulates centriole duplication

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png phosphorylation NPM1 0.515
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation NPM1 0.437
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation NPM1 0.537
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia
+ img/unknown.png phosphorylation NPM1 0.583
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation NPM1 0.418
Publications: 4 Organism: , Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation NPM1 0.537
Publications: 6 Organism: Homo Sapiens, Mus Musculus
Pathways:Acute Myeloid Leukemia
+ down-regulates activity img/direct_inhibition.png phosphorylation NPM1 0.421
Publications: 3 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation NPM1 0.583
Publications: 2 Organism: Mus Musculus, Homo Sapiens
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation FBP1 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding HEXIM1 0.4
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png binding NPM1 0.575
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, DNMT3A in AML, Onco-fusion proteins in AML, NPM1 in AML, AML_TRIPLETS, Triple mutant AML, NPM1_new
+ up-regulates quantity by stabilization img/direct-activation.png deubiquitination NPM1 0.4
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation HOXA9 0.363
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, DNMT3A in AML, Onco-fusion proteins in AML, AML_TRIPLETS, Triple mutant AML
+ up-regulates activity img/direct-activation.png binding CDKN2A 0.575
Publications: 1 Organism: Mus Musculus
Pathways:Acute Myeloid Leukemia, DNMT3A in AML, Onco-fusion proteins in AML, NPM1 in AML, AML_TRIPLETS, Triple mutant AML, NPM1_new
+ up-regulates quantity img/direct-activation.png binding FBXW7 0.498
Publications: 1 Organism: Mus Musculus
Pathways:Acute Myeloid Leukemia, DNMT3A in AML, NPM1 in AML, AML_TRIPLETS, Triple mutant AML, NPM1_new
+ up-regulates activity img/direct-activation.png binding CENPA 0.543
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination NPM1 0.2
Publications: 1 Organism: Homo Sapiens