Summary

Name NET1
Full Name Neuroepithelial cell-transforming gene 1 protein
Synonyms Proto-oncogene p65 Net1, Rho guanine nucleotide exchange factor 8 | ARHGEF8
Primary ID Q7Z628
Links - -
Type protein
Relations 4
Function Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase. May be involved in activation of the SAPK/JNK pathway Stimulates genotoxic stress-induced RHOB activity in breast cancer cells leading to their cell death.

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates activity img/direct_inhibition.png phosphorylation NET1 0.253
Publications: 3 Organism: In Vitro
+ up-regulates activity img/direct-activation.png guanine nucleotide exchange factor RHOA 0.822
Publications: 1 Organism: Homo Sapiens