4.0
Summary
| Name |  SPRED2
|
| Full Name | Sprouty-related, EVH1 domain-containing protein 2 |
| Synonyms | Spred-2 | |
| Primary ID | Q7Z698 |
| Links |  -  -  |
| Type | protein |
| Relations | 2 |
| Pathways | CROHN_DENDR, ULCERATIVE_COLITIS_IBD |
| Function | Negatively regulates Ras signaling pathways and downstream activation of MAP kinases (PubMed:15683364). Inhibits fibroblast growth factor (FGF)-induced retinal lens fiber differentiation, probably by inhibiting FGF-mediated phosphorylation of ERK1/2 (By similarity). Inhibits TGFB-induced epithelial-to-mesenchymal transition in lens epithelial cells (By similarity). |
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Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | hsa-mir-210-3p | down-regulates quantity by repression 
post transcriptional regulation
|
SPRED2 | 0.4 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | hsa-miR-31-5p | down-regulates quantity by repression
post transcriptional regulation
|
SPRED2 | 0.4 |
| Publications: | 1 | Organism: | Homo Sapiens | |