Membrane-associated RING finger protein 3, Membrane-associated RING-CH protein III, MARCH-III, RING finger protein 173, RING-type E3 ubiquitin transferase MARCHF3 | MARCH3, RNF173
Primary ID
Q86UD3
Links
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Type
protein
Relations
1
Function
E3 ubiquitin-protein ligase which may be involved in endosomal trafficking. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.
The ubiquitination process is mediated sequentially by three classes of enzymes consisting of a Ub-activating enzyme E1, a Ub-conjugating enzyme E2, and a Ub ligase E3. Ub is first activated by E1 in an adenosine 5′-triphosphate (ATP)-dependent manner t