3.0
Summary
| Name |  TLK2View Modifications |
| Full Name | Serine/threonine-protein kinase tousled-like 2 |
| Synonyms | HsHPK, PKU-alpha, Tousled-like kinase 2 | |
| Primary ID | Q86UE8 |
| Links |  -  -  |
| Type | protein |
| Relations | 3 |
| Function | Serine/threonine-protein kinase involved in the process of chromatin assembly and probably also DNA replication, transcription, repair, and chromosome segregation. Phosphorylates the chromatin assembly factors ASF1A AND ASF1B. Phosphorylation of ASF1A prevents its proteasome-mediated degradation, thereby enhancing chromatin assembly. Negative regulator of amino acid starvation-induced autophagy. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | TLK2 | up-regulates quantity by stabilization 
phosphorylation
|
ASF1A | 0.693 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | TLK2 |
phosphorylation
|
ASF1B | 0.725 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | CHEK1 | down-regulates activity 
phosphorylation
|
TLK2 | 0.275 |
| Publications: | 1 | Organism: | In Vitro | |