3.0
Summary
| Name |  ASF1AView Modifications |
| Full Name | Histone chaperone ASF1A |
| Synonyms | Anti-silencing function protein 1 homolog A, hAsf1, hAsf1a, CCG1-interacting factor A, CIA, hCIA | |
| Primary ID | Q9Y294 |
| Links |  -  -  |
| Type | protein |
| Relations | 4 |
| Function | Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly and with HIRA to promote replication-independent chromatin assembly. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | CHEK1 | up-regulates activity 
phosphorylation
|
ASF1A | 0.42 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | TLK2 | up-regulates quantity by stabilization
phosphorylation
|
ASF1A | 0.681 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | ASF1A | up-regulates activity
binding
|
MDC1 | 0.315 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | MDM2 | down-regulates quantity by destabilization 
ubiquitination
|
ASF1A | 0.269 |
| Publications: | 1 | Organism: | Homo Sapiens | |