Relation Results

Summary

Name CADPS2
Full Name Calcium-dependent secretion activator 2
Synonyms Calcium-dependent activator protein for secretion 2, CAPS-2 | CAPS2, KIAA1591
Primary ID Q86UW7
Links - -
Type protein
Relations 6
Function Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the bi ...
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Type: Score: Layout: SPV 
0.3610.2680.2770.2960.80.256CADPS2STX1ASNAP25SNCALRRK2phosphatidylinositol bisphosphateVAMP2

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Relations
Regulator
Mechanism
target
score ℹ
+ CADPS2up-regulates activity img/direct-activation.png binding STX1A 0.361
Identifier Residue Sequence Organism Cell Line
SIGNOR-264337 Homo sapiens Neuron
pmid sentence
CAPS interacted independently with either syntaxin-1 or SNAP-25 suggesting that CAPS might promote QaQbc-SNARE heterodimer formation. CAPS binding to syntaxin-1 was mediated by the membrane-proximal C-terminal SNARE motif (H3) and membrane linker domain sequences of syntaxin-1
Publications: 1 Organism: Homo Sapiens
+ CADPS2up-regulates activity img/direct-activation.png binding SNAP25 0.268
Identifier Residue Sequence Organism Cell Line
SIGNOR-264339 Homo sapiens Neuron
pmid sentence
CAPS interacted independently with either syntaxin-1 or SNAP-25 suggesting that CAPS might promote QaQbc-SNARE heterodimer formation. CAPS binding to syntaxin-1 was mediated by the membrane-proximal C-terminal SNARE motif (H3) and membrane linker domain sequences of syntaxin-1
Publications: 1 Organism: Homo Sapiens
+ SNCAdown-regulates quantity img/indirect_inhibition.png transcriptional regulation CADPS2 0.277
Identifier Residue Sequence Organism Cell Line
SIGNOR-268929 Homo sapiens
pmid sentence
This approach enabled us to disclose a differential effect of high levels of LRRK2 and aSyn on CADPS2 promoter activity. Specifically, CADPS2 transcriptional activity was enhanced by high cellular levels of LRRK2 and reduced by overexpression of aSyn. Consistently, CADPS2 mRNA levels were diminished in aSyn overexpressing cells.
Publications: 1 Organism: Homo Sapiens
+ LRRK2up-regulates quantity img/indirect-activation.png transcriptional regulation CADPS2 0.296
Identifier Residue Sequence Organism Cell Line
SIGNOR-268928 Homo sapiens
pmid sentence
This approach enabled us to disclose a differential effect of high levels of LRRK2 and aSyn on CADPS2 promoter activity. Specifically, CADPS2 transcriptional activity was enhanced by high cellular levels of LRRK2 and reduced by overexpression of aSyn. Consistently, CADPS2 mRNA levels were diminished in aSyn overexpressing cells.
Publications: 1 Organism: Homo Sapiens
+ phosphatidylinositol bisphosphateup-regulates activity img/direct-activation.png chemical activation CADPS2 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-264335 Homo sapiens Neuron
pmid sentence
CAPS exhibits low affinity but functionally significant interactions with plasma membrane PIP2 via its central PH (pleckstrin homology) domain (82, 111). PIP2 enhanced CAPS stimulation of SNARE-dependent liposome fusion with wild-type but not with mutant PH domain CAPS proteins
Publications: 1 Organism: Homo Sapiens
+ CADPS2up-regulates activity img/direct-activation.png binding VAMP2 0.256
Identifier Residue Sequence Organism Cell Line
SIGNOR-264341 Homo sapiens Neuron
pmid sentence
CAPS interactions with N-terminal regions of the SNARE motif of VAMP2 were also detected, which suggests that CAPS might recruit VAMP2 into syntaxin-1/SNAP-25 heterodimers for RQaQbc-SNARE complex assembly.
Publications: 1 Organism: Homo Sapiens
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