| + |
CADPS2 | up-regulates activity 
binding
|
VAMP2 |
0.257 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264341 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 24363652 |
CAPS interactions with N-terminal regions of the SNARE motif of VAMP2 were also detected, which suggests that CAPS might recruit VAMP2 into syntaxin-1/SNAP-25 heterodimers for RQaQbc-SNARE complex assembly. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SNCA | down-regulates quantity 
transcriptional regulation
|
CADPS2 |
0.279 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268929 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 28647363 |
This approach enabled us to disclose a differential effect of high levels of LRRK2 and aSyn on CADPS2 promoter activity. Specifically, CADPS2 transcriptional activity was enhanced by high cellular levels of LRRK2 and reduced by overexpression of aSyn. Consistently, CADPS2 mRNA levels were diminished in aSyn overexpressing cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CADPS2 | up-regulates activity
binding
|
SNAP25 |
0.269 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264339 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 24363652 |
CAPS interacted independently with either syntaxin-1 or SNAP-25 suggesting that CAPS might promote QaQbc-SNARE heterodimer formation. CAPS binding to syntaxin-1 was mediated by the membrane-proximal C-terminal SNARE motif (H3) and membrane linker domain sequences of syntaxin-1 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CADPS2 | up-regulates activity
binding
|
STX1A |
0.364 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264337 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 24363652 |
CAPS interacted independently with either syntaxin-1 or SNAP-25 suggesting that CAPS might promote QaQbc-SNARE heterodimer formation. CAPS binding to syntaxin-1 was mediated by the membrane-proximal C-terminal SNARE motif (H3) and membrane linker domain sequences of syntaxin-1 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
phosphatidylinositol bisphosphate | up-regulates activity
chemical activation
|
CADPS2 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264335 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 24363652 |
CAPS exhibits low affinity but functionally significant interactions with plasma membrane PIP2 via its central PH (pleckstrin homology) domain (82, 111). PIP2 enhanced CAPS stimulation of SNARE-dependent liposome fusion with wild-type but not with mutant PH domain CAPS proteins |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
LRRK2 | up-regulates quantity 
transcriptional regulation
|
CADPS2 |
0.297 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268928 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 28647363 |
This approach enabled us to disclose a differential effect of high levels of LRRK2 and aSyn on CADPS2 promoter activity. Specifically, CADPS2 transcriptional activity was enhanced by high cellular levels of LRRK2 and reduced by overexpression of aSyn. Consistently, CADPS2 mRNA levels were diminished in aSyn overexpressing cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
CADPS2
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