Summary

Name THOC6
Full Name THO complex subunit 6 homolog
Synonyms Functional spliceosome-associated protein 35, fSAP35, WD repeat-containing protein 58 | WDR58
Primary ID Q86W42
Links - -
Type protein
Relations 1
Function Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. Plays a role in apoptosis negative control involved in brain development.

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Relations

Regulator Mechanism target score ℹ
+ THOC6form complex img/form-complex.png binding TREX complex 0.908
Publications: 1 Organism: Homo Sapiens