Summary

Name DHFR2
Full Name Dihydrofolate reductase 2, mitochondrial
Synonyms Dihydrofolate reductase, mitochondrial, 1.5.1.3, Dihydrofolate reductase-like protein 1 | DHFRL1, DHFRP4
Primary ID Q86XF0
Links - -
Type protein
Relations 2
Function Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Required to prevent uracil accumulation in mtDNA. Binds its own mRNA and that of DHFR.

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Relations

Regulator Mechanism target score
+ up-regulates quantity img/direct-activation.png chemical modification (6S)-5,6,7,8-tetrahydrofolate(2-) 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity img/direct_inhibition.png chemical modification dihydrofolate(2-) 0.8
Publications: 1 Organism: Homo Sapiens