Summary

Name ANKLE2
Full Name Ankyrin repeat and LEM domain-containing protein 2
Synonyms LEM domain-containing protein 4 | KIAA0692, LEM4
Primary ID Q86XL3
Links - -
Type protein
Relations 1
Function Involved in mitotic nuclear envelope reassembly by promoting dephosphorylation of BAF/BANF1 during mitotic exit (PubMed:22770216). Coordinates the control of BAF/BANF1 dephosphorylation by inhibiting VRK1 kinase and promoting dephosphorylation of BAF/BANF1 by protein phosphatase 2A (PP2A), thereby facilitating nuclear envelope assembly (PubMed:22770216). May regulate nuclear localization of VRK1 in non-dividing cells (PubMed:31735666). It is unclear whether it acts as a real PP2A regulatory subunit or whether it is involved in recruitment of the PP2A complex (PubMed:22770216). Involved in brain development (PubMed:25259927).

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Relations

Regulator Mechanism target score ℹ
+ ANKLE2down-regulates img/indirect_inhibition.png VRK1 0.79
Publications: 1 Organism: Homo Sapiens