3.0
Summary
| Name |  TRIM50
|
| Full Name | E3 ubiquitin-protein ligase TRIM50 |
| Synonyms | RING-type E3 ubiquitin transferase TRIM50, Tripartite motif-containing protein 50 | TRIM50A |
| Primary ID | Q86XT4 |
| Links |  -  -  |
| Type | protein |
| Relations | 1 |
| Function | E3 ubiquitin-protein ligase that ubiquitinates Beclin-1/BECN1 in a 'Lys-63'-dependent manner enhancing its binding to ULK1. In turn, promotes starvation-induced autophagy activation. Interacts also with p62/SQSTM1 protein and thereby induces the formation and the autophagy clearance of aggresome-associated polyubiquitinated proteins through HDAC6 interaction. |
ubiquitination