Summary

Name TRIM50
Full Name E3 ubiquitin-protein ligase TRIM50
Synonyms RING-type E3 ubiquitin transferase TRIM50, Tripartite motif-containing protein 50 | TRIM50A
Primary ID Q86XT4
Links - -
Type protein
Relations 1
Function E3 ubiquitin-protein ligase that ubiquitinates Beclin-1/BECN1 in a 'Lys-63'-dependent manner enhancing its binding to ULK1. In turn, promotes starvation-induced autophagy activation. Interacts also with p62/SQSTM1 protein and thereby induces the formation and the autophagy clearance of aggresome-associated polyubiquitinated proteins through HDAC6 interaction.

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Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png ubiquitination TRIM50 0.2
Publications: 1 Organism: Homo Sapiens